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Peptide record

TPDB13296

Antibacterial Anticancer Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB13296
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, DRAMP, and Peptipedia, with an available 3D structural model.
Sequence
KTMMQSGGTFGTFMAIGMGIR
Physicochemical Analysis
C95H156N26O27S4
NDCEHLPWYV
G
2222.68
11.49
2
0
9
+2
-0.99
0.343
41.90
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
5
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
1
Q
5
G
0
H
2
I
0
L
1
K
4
M
2
F
0
P
1
S
3
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 5 H: 0 I: 2 L: 0 K: 1 M: 4 F: 2 P: 0 S: 1 T: 3 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C95H156N26O27S4
2222.68
11.49
+2
-0.99
0.343
Evidence Records 8 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

DRAMP

Other

(APD converted ug/ml to uM): moderately active against Gram+ S. aureus (MBC 45 uM), B. subtilis (MBC 41 uM), E. faecium (MBC 38 uM), S. sindenensis (MBC 43 uM), E. faecalis (MBC 38 uM), S. pneumoniae (MBC 45 uM), Gram- E. coli (MBC 38 uM), P. aeruginosa, K. pneumoniae, A. baumannii (MBC 45 uM), E. aerogenes (MBC 41 uM), MDR pathogens MRSA (MBC 45 uM), Vancomycin-resistant S. aureus (MBC 54 uM), Vancomycin-resistant E. faecium (anti-VRE, MBC 45 uM), Carbapenem-resistant P. aeruginosa, Carbapenem-resistant A. baumannii (MBC 50 uM), and Carbapenem-resistant K. pneumoniae (MBC 45 uM).
Evidence 2 Activity

Activity

20% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
20% Hemolysis | 256 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Romo1-Derived Antimicrobial Peptide Is a New Antimicrobial Agent Against Multidrug-Resistant Bacteria in a Murine Model of Sepsis. | MBio | 2020
Evidence 3 Activity

Activity

20% Killing
Toxicity
256 µg/mL
Cytotoxic
20% Killing | 256 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Romo1-Derived Antimicrobial Peptide Is a New Antimicrobial Agent Against Multidrug-Resistant Bacteria in a Murine Model of Sepsis. | MBio | 2020
Evidence 4 Activity

Activity

20% Killing
Toxicity
256 µg/mL
Cytotoxic
20% Killing | 256 | µg/mL | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Romo1-Derived Antimicrobial Peptide Is a New Antimicrobial Agent Against Multidrug-Resistant Bacteria in a Murine Model of Sepsis. | MBio | 2020
Evidence 5 Activity

Activity

30% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
30% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A Novel Peptide Derived from the Transmembrane Domain of Romo1 Is a Promising Candidate for Sepsis Treatment and Multidrug-Resistant Bacteria. | Int J Mol Sci | 2021
Evidence 6 Activity

Activity

9% Cytotoxicity
Toxicity
256 µg/mL
Cytotoxic
9% Cytotoxicity | 256 | µg/mL | target cell: Human leukocytes

Target

Human leukocytes

Source & Reference

NA
DBAASP
A Novel Peptide Derived from the Transmembrane Domain of Romo1 Is a Promising Candidate for Sepsis Treatment and Multidrug-Resistant Bacteria. | Int J Mol Sci | 2021
Evidence 7 Activity

Activity

5% Cytotoxicity
Toxicity
256 µg/mL
Cytotoxic
5% Cytotoxicity | 256 | µg/mL | target cell: Mouse leukocytes

Target

Mouse leukocytes

Source & Reference

NA
DBAASP
A Novel Peptide Derived from the Transmembrane Domain of Romo1 Is a Promising Candidate for Sepsis Treatment and Multidrug-Resistant Bacteria. | Int J Mol Sci | 2021
Evidence 8 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.33291307]At the concentration of 32 µg/mL, AMPR-11 induced a hemolysis of 20% on mouse red blood cells At the concentration of 256 µg/mL, AMPR-11 induced a hemolysis of 23%. | Cytotoxicity: [Ref.33291307] ①The cell viability of HeLa cells was 90%, 87%, 83% and 79% at the concentration of 32, 64, 128 and 256 µg/mL. ②The cell viability of HEK293 cells was 86%, 83%, 80% and 78% at the concentration of 32, 64, 128 and 256 µg/mL. ③The cell viability of HeLa cells was 89%, 86%, 83% and 80% at the concentration of 32, 64, 128 and 256 µg/mL.

Target

erythrocytes

Source & Reference

NA
DRAMP
mBio. 2020 Apr 14 11(2):e03258-19. doi: 10.1128/mBio.03258-19.