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Peptide record

TPDB13293

Antibacterial Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB13293
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IIGGLFSAGKAIHRLIRRRRR
Physicochemical Analysis
C108H192N42O23
NDCEQMPTWYV
R
2446.98
13.10
8
0
9
+7
3.14
-0.195
120.95
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
2
A
6
R
0
N
0
D
0
C
0
E
0
Q
3
G
1
H
4
I
2
L
1
K
0
M
1
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 1 I: 4 L: 2 K: 1 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C108H192N42O23
2446.98
13.10
+7
3.14
-0.195
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
150 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 150 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4. | PLoS One | 2017
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic
Hemolytic_activity: [Ref.29040295] 10% haemolysis haemolysis at 12.50 µg/ml, 12% haemolysis haemolysis at 25.00 µg/ml, 20% haemolysis haemolysis at 50.00 µg/ml, 35% haemolysis haemolysis at 100.00 µg/ml, 75% haemolysis haemolysis at 200.00 µg/ml, 100% haemolysis haemolysis at 400.00 µg/ml, 100% haemolysis haemolysis at 800.00 µg/ml against mouse red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
PLoS One. 2017 Oct 17 12(10):e0186442.