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Peptide record

TPDB13289

Antibacterial Anticancer Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB13289
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
AFCWNVCVYRNAVRVCHRRCN
Physicochemical Analysis
C109H169N39O26S4
DEQGILKMPST
RCV
2570.03
9.27
5
0
9
+4
0.52
-0.033
64.76
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
7240
281.71
8
Residue Composition
number
2
A
4
R
3
N
0
D
4
C
0
E
0
Q
0
G
1
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
1
W
1
Y
4
V
Amino Acid Distribution
A: 2 R: 4 N: 3 D: 0 C: 4 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 4
Chemical Descriptors
21
C109H169N39O26S4
2570.03
9.27
+4
0.52
-0.033
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1 µg/mL

Target

S. typhimurium ATCC14028

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
bacteria E. coli CVCC195 or CVCC1515 or CICC21530 serotype O157:H7 (MIC 0.25-0.5 ug/ml), S. typhimurium ATCC14028 (MIC 1 ug/ml), S. enteritidis CVCC3377 (MIC 0.125 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.25-0.
Evidence 2 Activity

Activity

MIC
Antibacterial
0.125 µg/mL

Target

S. enteritidis CVCC3377

Source & Reference

dbAMP

Other

CICC21530 serotype O157:H7 (MIC 0.25-0.5 ug/ml), S. typhimurium ATCC14028 (MIC 1 ug/ml), S. enteritidis CVCC3377 (MIC 0.125 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.25-0.50 ug/ml), S. choleraesuis CVCC503 (MIC 0.5
Evidence 3 Activity

Activity

MIC
Antibacterial
0.25-0.50 µg/mL

Target

S. pullorum CVCC1789 or CVCC1802

Source & Reference

dbAMP

Other

g/ml), S. typhimurium ATCC14028 (MIC 1 ug/ml), S. enteritidis CVCC3377 (MIC 0.125 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.25-0.50 ug/ml), S. choleraesuis CVCC503 (MIC 0.5 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 2 ug/
Evidence 4 Activity

Activity

MIC
Antibacterial
0.5 µg/mL

Target

S. choleraesuis CVCC503

Source & Reference

dbAMP

Other

tidis CVCC3377 (MIC 0.125 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.25-0.50 ug/ml), S. choleraesuis CVCC503 (MIC 0.5 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 2 ug/ml), Gram+ S. aureus ATCC43300 MRSA or AT
Evidence 5 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

Pseudomonas aeruginosa CICC10419 or CICC21630

Source & Reference

dbAMP

Other

orum CVCC1789 or CVCC1802 (MIC 0.25-0.50 ug/ml), S. choleraesuis CVCC503 (MIC 0.5 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 2 ug/ml), Gram+ S. aureus ATCC43300 MRSA or ATCC25923 (MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16
Evidence 6 Activity

Activity

MIC
Antibacterial
0.25-16 µg/mL

Target

Staphylococcus aureus ATCC43300 MRSA or ATCC25923

Source & Reference

dbAMP

Other

aesuis CVCC503 (MIC 0.5 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 2 ug/ml), Gram+ S. aureus ATCC43300 MRSA or ATCC25923 (MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16 ug/ml), E. faecium CMCC1.2136 (MIC 4 ug/ml), B. subtilis ATCC663
Evidence 7 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

S. suis CVCC606

Source & Reference

dbAMP

Other

CICC21630 (MIC 2 ug/ml), Gram+ S. aureus ATCC43300 MRSA or ATCC25923 (MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16 ug/ml), E. faecium CMCC1.2136 (MIC 4 ug/ml), B. subtilis ATCC6633 (MIC 0.5 ug/ml), L. ivanovii A
Evidence 8 Activity

Activity

MIC
Antibacterial
0.5 µg/mL

Target

B. subtilis ATCC6633

Source & Reference

dbAMP

Other

(MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16 ug/ml), E. faecium CMCC1.2136 (MIC 4 ug/ml), B. subtilis ATCC6633 (MIC 0.5 ug/ml), L. ivanovii ATCC19119 (MIC 4 ug/ml), fungi C. albicans CGMCC2.2411 (MIC 32 ug/ml).
Evidence 9 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

L. ivanovii ATCC19119

Source & Reference

dbAMP

Other

MIC 16 ug/ml), E. faecium CMCC1.2136 (MIC 4 ug/ml), B. subtilis ATCC6633 (MIC 0.5 ug/ml), L. ivanovii ATCC19119 (MIC 4 ug/ml), fungi C. albicans CGMCC2.2411 (MIC 32 ug/ml).
Evidence 10 Activity

Activity

MIC
Antifungal
1 µg/mL

Target

S. typhimurium ATCC14028

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
bacteria E. coli CVCC195 or CVCC1515 or CICC21530 serotype O157:H7 (MIC 0.25-0.5 ug/ml), S. typhimurium ATCC14028 (MIC 1 ug/ml), S. enteritidis CVCC3377 (MIC 0.125 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.25-0.
Evidence 11 Activity

Activity

MIC
Antifungal
0.125 µg/mL

Target

S. enteritidis CVCC3377

Source & Reference

dbAMP CAFPdb Antifungipept

Other

CICC21530 serotype O157:H7 (MIC 0.25-0.5 ug/ml), S. typhimurium ATCC14028 (MIC 1 ug/ml), S. enteritidis CVCC3377 (MIC 0.125 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.25-0.50 ug/ml), S. choleraesuis CVCC503 (MIC 0.5
Evidence 12 Activity

Activity

MIC
Antifungal
0.25-0.50 µg/mL

Target

S. pullorum CVCC1789 or CVCC1802

Source & Reference

dbAMP CAFPdb Antifungipept

Other

g/ml), S. typhimurium ATCC14028 (MIC 1 ug/ml), S. enteritidis CVCC3377 (MIC 0.125 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.25-0.50 ug/ml), S. choleraesuis CVCC503 (MIC 0.5 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 2 ug/
Evidence 13 Activity

Activity

MIC
Antifungal
0.5 µg/mL

Target

S. choleraesuis CVCC503

Source & Reference

dbAMP CAFPdb Antifungipept

Other

tidis CVCC3377 (MIC 0.125 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.25-0.50 ug/ml), S. choleraesuis CVCC503 (MIC 0.5 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 2 ug/ml), Gram+ S. aureus ATCC43300 MRSA or AT
Evidence 14 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

Pseudomonas aeruginosa CICC10419 or CICC21630

Source & Reference

dbAMP CAFPdb Antifungipept

Other

orum CVCC1789 or CVCC1802 (MIC 0.25-0.50 ug/ml), S. choleraesuis CVCC503 (MIC 0.5 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 2 ug/ml), Gram+ S. aureus ATCC43300 MRSA or ATCC25923 (MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16
Evidence 15 Activity

Activity

MIC
Antifungal
0.25-16 µg/mL

Target

Staphylococcus aureus ATCC43300 MRSA or ATCC25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

aesuis CVCC503 (MIC 0.5 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 2 ug/ml), Gram+ S. aureus ATCC43300 MRSA or ATCC25923 (MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16 ug/ml), E. faecium CMCC1.2136 (MIC 4 ug/ml), B. subtilis ATCC663
Evidence 16 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

S. suis CVCC606

Source & Reference

dbAMP CAFPdb Antifungipept

Other

CICC21630 (MIC 2 ug/ml), Gram+ S. aureus ATCC43300 MRSA or ATCC25923 (MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16 ug/ml), E. faecium CMCC1.2136 (MIC 4 ug/ml), B. subtilis ATCC6633 (MIC 0.5 ug/ml), L. ivanovii A
Evidence 17 Activity

Activity

MIC
Antifungal
0.5 µg/mL

Target

B. subtilis ATCC6633

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16 ug/ml), E. faecium CMCC1.2136 (MIC 4 ug/ml), B. subtilis ATCC6633 (MIC 0.5 ug/ml), L. ivanovii ATCC19119 (MIC 4 ug/ml), fungi C. albicans CGMCC2.2411 (MIC 32 ug/ml).
Evidence 18 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

L. ivanovii ATCC19119

Source & Reference

dbAMP CAFPdb Antifungipept

Other

MIC 16 ug/ml), E. faecium CMCC1.2136 (MIC 4 ug/ml), B. subtilis ATCC6633 (MIC 0.5 ug/ml), L. ivanovii ATCC19119 (MIC 4 ug/ml), fungi C. albicans CGMCC2.2411 (MIC 32 ug/ml).
Evidence 19 Activity

Activity

0.4% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
0.4% Hemolysis | 128 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Antibacterial and detoxifying activity of NZ17074 analogues with multi-layers of selective antimicrobial actions against Escherichia coli and Salmonella enteritidis. | Sci Rep | 2017
Evidence 20 Activity

Activity

3.8% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
3.8% Hemolysis | 256 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Antibacterial and detoxifying activity of NZ17074 analogues with multi-layers of selective antimicrobial actions against Escherichia coli and Salmonella enteritidis. | Sci Rep | 2017