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Peptide record

TPDB13283

Antibacterial Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB13283
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
LKKLCARLKKLCARLKKLCAR
Physicochemical Analysis
C108H206N36O22S3
NDEQGHIMFPSTWYV
LK
2457.23
11.14
9
0
9
+9
3.78
-0.057
125.71
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
125
5.09
3
Residue Composition
number
3
A
3
R
0
N
0
D
3
C
0
E
0
Q
0
G
0
H
0
I
6
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 3 N: 0 D: 0 C: 3 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 6 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C108H206N36O22S3
2457.23
11.14
+9
3.78
-0.057
Evidence Records 2 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
10% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of Heptad Repeat Amphiphiles Based on Database Filtering and Structure-Function Relationships to Combat Drug-Resistant Fungi and Biofilms | ACS Appl Mater Interfaces | 2020
Evidence 2 Activity

Activity

45% Cell death
Toxicity
128 µM
Cytotoxic
45% Cell death | 128 | µM | target cell: Mouse primary corneal epithelial cells (MPCE)

Target

Mouse primary corneal epithelial cells (MPCE)

Source & Reference

NA
DBAASP
Design of Heptad Repeat Amphiphiles Based on Database Filtering and Structure-Function Relationships to Combat Drug-Resistant Fungi and Biofilms | ACS Appl Mater Interfaces | 2020