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Peptide record

TPDB13266

Antibacterial Anticancer Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB13266
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
HIAGLAANFLPQILCKIARKC
Physicochemical Analysis
C103H174N30O24S2
DEMSTWYV
A
2280.82
9.92
4
0
11
+3
0.31
0.733
130.48
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
125
5.48
4
Residue Composition
number
4
A
1
R
1
N
0
D
2
C
0
E
1
Q
1
G
1
H
3
I
3
L
2
K
0
M
1
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 1 G: 1 H: 1 I: 3 L: 3 K: 2 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C103H174N30O24S2
2280.82
9.92
+3
0.31
0.733
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
>100 µg/mL
Cytotoxic
50% Cytotoxicity | >100 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides. | PLoS One | 2015
Evidence 2 Activity

Activity

50% Cytotoxicity
Toxicity
90±2.56 µg/mL
Cytotoxic
50% Cytotoxicity | 90±2.56 | µg/mL | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides. | PLoS One | 2015
Evidence 3 Activity

Activity

30.4% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
30.4% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides. | PLoS One | 2015
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
30.4 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 30.4% Hemolysis=200 µg/ml | Cytotoxicity: HEK293: 50%Cytotoxicity>100 µg/ml PBMC: 50%Cytotoxicity=90±2.56 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
PLoS One. 2015 May 21 10(5):e0124210.