Back to search

Peptide record

TPDB13264

Antibacterial Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB13264
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse CAFPdb
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RWKRHISEQLRRRDRLQRQAF
Physicochemical Analysis
C122H203N49O30
NCGMPTYV
R
2836.26
12.53
9
2
6
+6
8.16
-1.957
60.48
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
193.92
4
Residue Composition
number
1
A
7
R
0
N
1
D
0
C
1
E
3
Q
0
G
1
H
1
I
2
L
1
K
0
M
1
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 7 N: 0 D: 1 C: 0 E: 1 Q: 3 G: 0 H: 1 I: 1 L: 2 K: 1 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
21
C122H203N49O30
2836.26
12.53
+6
8.16
-1.957
Evidence Records 2 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
500 µM
Hemolytic Cytotoxic
0% Hemolysis | 500 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Design, Synthesis, Antibacterial Potential, and Structural Characterization of N-Acylated Derivatives of the Human Autophagy 16 Polypeptide. | Bioconjug Chem | 2019
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
3 %
Hemolytic
Hemolytic_activity: [Ref.31145591] 3% hemolysis at 500µM, 16% hemolysis at 600 µM, 27% hemolysis at 700 µM, 38% hemolysis at 800 µM, 50% hemolysis at 900 µM, 62% hemolysis at 1000µM against mouse blood cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
Bioconjug Chem. 2019 Jun 18. doi: 10.1021/acs.bioconjchem.9b00290.