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Peptide record

TPDB13246

Antibacterial Antifungal Toxicity standard

20 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB13246

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 20-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.

Sequence

FLREFHKWIERVVGWLGKVF

FASTA

>TPDB13246|Antibacterial;Antifungal;Toxicity|length=20
FLREFHKWIERVVGWLGKVF

Formula C126H184N32O25

Absent Amino Acids ANDCQMPSTY

Common Amino Acids FV

Mass 2547.05

PI 10.57

Basic Residues 5

Acidic Residues 2

Hydrophobic Residues 11

Net Charge +2

Boman Index 0.31

Hydrophobicity 0.175

Aliphatic Index 102.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 11000

Absorbance 280nm 431.87

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 0 C: 0 E: 2 Q: 0 G: 2 H: 1 I: 1 L: 2 K: 2 M: 0 F: 3 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 3

Length

Formula

C126H184N32O25

Mass

2547.05

10.57

Net Charge

Boman Index

0.31

Hydrophobicity

0.175

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

active against S. aureus ATCC 25923 (MIC 32 uM), S. epidermidis (MIC 21 uM), and C. albicans (MIC 32 uM). Inactive: T.rubrum (MIC 256 uM)

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 21 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against S. aureus ATCC 25923 (MIC 32 uM), S. epidermidis (MIC 21 uM), and C. albicans (MIC 32 uM). Inactive: T.rubrum (MIC 256 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against S. aureus ATCC 25923 (MIC 32 uM), S. epidermidis (MIC 21 uM), and C. albicans (MIC 32 uM). Inactive: T.rubrum (MIC 256 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 256 µM

Target

Target Organism T.rubrum

Source & Reference

Database Source dbAMP

Other

Evidence Text

TCC 25923 (MIC 32 uM), S. epidermidis (MIC 21 uM), and C. albicans (MIC 32 uM). Inactive: T.rubrum (MIC 256 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 32 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

active against S. aureus ATCC 25923 (MIC 32 uM), S. epidermidis (MIC 21 uM), and C. albicans (MIC 32 uM). Inactive: T.rubrum (MIC 256 uM)

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 21 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

active against S. aureus ATCC 25923 (MIC 32 uM), S. epidermidis (MIC 21 uM), and C. albicans (MIC 32 uM). Inactive: T.rubrum (MIC 256 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 32 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

active against S. aureus ATCC 25923 (MIC 32 uM), S. epidermidis (MIC 21 uM), and C. albicans (MIC 32 uM). Inactive: T.rubrum (MIC 256 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 256 µM

Target

Target Organism T.rubrum

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

TCC 25923 (MIC 32 uM), S. epidermidis (MIC 21 uM), and C. albicans (MIC 32 uM). Inactive: T.rubrum (MIC 256 uM).

Evidence 9 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >128 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

A small mycobacteriophage-derived peptide and its improved isomer restrict mycobacterial infection via dual mycobactericidal-immunoregulatory activities.Intragenic antimicrobial peptides (IAPs) from human proteins with potent antimicrobial and anti-inflammatory activity. | PLoS One | 2019

Evidence 10 Activity

Activity

Activity Endpoint 0% Killing

Detail Source Activity Toxicity

Activity Measurement 10 µM

Toxicity Type Cytotoxic

Toxicity Raw

0% Killing | 10 | µM | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Evidence 11 Activity

Activity

Activity Endpoint 75% Killing

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Cytotoxic

Toxicity Raw

75% Killing | 100 | µM | target cell: Murine peritoneal macrophages

Target

Target Cell Murine peritoneal macrophages

Source & Reference

Database Source NA

Source Database DBAASP

Reference