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Peptide record

TPDB13216

Antibacterial Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB13216
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
LRRLKPLIRPWLRPLRRWWW
Physicochemical Analysis
C137H213N43O21
ANDCEQGHMFSTYV
R
2798.47
13.10
7
0
10
+7
-3.31
-0.790
117.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
22000
786.14
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
5
L
1
K
0
M
0
F
3
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 5 K: 1 M: 0 F: 0 P: 3 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
20
C137H213N43O21
2798.47
13.10
+7
-3.31
-0.790
Evidence Records 7 records
Evidence 1 Activity

Activity

3.6% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
3.6% Hemolysis | 128 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018
Evidence 2 Activity

Activity

10.1% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
10.1% Hemolysis | 256 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018
Evidence 3 Activity

Activity

17.5% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
17.5% Hemolysis | 512 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018
Evidence 4 Activity

Activity

20% Killing
Toxicity
64 µg/mL
Cytotoxic
20% Killing | 64 | µg/mL | target cell: Murine dendritic cells JAWS II

Target

Murine dendritic cells JAWS II

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018
Evidence 5 Activity

Activity

77% Killing
Toxicity
512 µg/mL
Cytotoxic
77% Killing | 512 | µg/mL | target cell: Murine dendritic cells JAWS II

Target

Murine dendritic cells JAWS II

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018
Evidence 6 Activity

Activity

<5% Killing
Toxicity
64 µg/mL
Cytotoxic
<5% Killing | 64 | µg/mL | target cell: Chinese hamster ovary cells CHO-K1

Target

Chinese hamster ovary cells CHO-K1

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018
Evidence 7 Activity

Activity

77% Killing
Toxicity
512 µg/mL
Cytotoxic
77% Killing | 512 | µg/mL | target cell: Chinese hamster ovary cells CHO-K1

Target

Chinese hamster ovary cells CHO-K1

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018