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Peptide record

TPDB13213

Antibacterial Anticancer Antifungal Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB13213
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia dbACP AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 20-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KRIGLIRLIGKILRGLRRLG
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C104H197N37O21
ANDCEQHMFPSTWYV
RL
2301.94
13.01
7
0
9
+7
1.88
0.255
175.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
4
G
0
H
4
I
5
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 4 L: 5 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
20 reviewed residue count
C104H197N37O21 sequence-only estimate (linear, free termini)
2301.94 sequence-only estimate (linear, free termini)
13.01 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
1.88 sequence-only estimate (linear, free termini)
0.255 sequence-only estimate (linear, free termini)
Evidence Records 5 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
1-31.25 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 1-31.25 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cathelicidins in the Tasmanian devil (Sarcophilus harrisii). | Sci Rep | 2016
Evidence 2 Activity

Activity

7% Hemolysis
Toxicity
62.5 µg/mL
Hemolytic Cytotoxic
7% Hemolysis | 62.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cathelicidins in the Tasmanian devil (Sarcophilus harrisii). | Sci Rep | 2016
Evidence 3 Activity

Activity

12% Hemolysis
Toxicity
125 µg/mL
Hemolytic Cytotoxic
12% Hemolysis | 125 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cathelicidins in the Tasmanian devil (Sarcophilus harrisii). | Sci Rep | 2016
Evidence 4 Activity

Activity

30% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
30% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cathelicidins in the Tasmanian devil (Sarcophilus harrisii). | Sci Rep | 2016
Evidence 5 Activity

Activity

% Hemolysis
Toxicity
5 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes:5% Hemolysis=1-31.25µg/ml 7% Hemolysis=62.5µg/ml 12% Hemolysis=125µg/ml 30% Hemolysis=250µg/ml | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2016 Oct 11 6:35019.