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Peptide record

TPDB13200

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard

20 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB13200

Activity

Antibacterial Anticancer Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.

Sequence

FIVPSIFLLKKAFCIALKKC

FASTA

>TPDB13200|Antibacterial;Anticancer;Antifungal;Hemolysis;Toxicity|length=20
FIVPSIFLLKKAFCIALKKC

Formula C112H184N24O22S2

Absent Amino Acids RNDEQGHMTWY

Common Amino Acids K

Mass 2282.96

PI 10.17

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +4

Boman Index -2.21

Hydrophobicity 1.405

Aliphatic Index 141.50

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 125

Absorbance 280nm 5.48

Polar Residues 3

number

Amino Acid Distribution

A: 2 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 3 K: 4 M: 0 F: 3 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1

Length

Formula

C112H184N24O22S2

Mass

2282.96

10.17

Net Charge

Boman Index

-2.21

Hydrophobicity

1.405

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Staphylococcus aureus NCTC 10788 or MRSA NCTC 12493

Source & Reference

Database Source NA

Other

Evidence Text

active against S. aureus NCTC 10788 or MRSA NCTC 12493 (MIC 4 uM), MRSA B038 V1S1 A (MIC 8 uM), E. coli NCTC 10418 (MIC 16 uM), P.aeruginosa ATCC 27853 (MI

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µM

Target

Target Organism Escherichia coli NCTC 10418

Source & Reference

Database Source NA

Other

Evidence Text

against S. aureus NCTC 10788 or MRSA NCTC 12493 (MIC 4 uM), MRSA B038 V1S1 A (MIC 8 uM), E. coli NCTC 10418 (MIC 16 uM), P.aeruginosa ATCC 27853 (MIC >512 uM), and C. albicans NCYC 1467 (MIC 4 uM). Also antibi

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >512 µM

Target

Target Organism P.aeruginosa ATCC 27853

Source & Reference

Database Source NA

Other

Evidence Text

MRSA NCTC 12493 (MIC 4 uM), MRSA B038 V1S1 A (MIC 8 uM), E. coli NCTC 10418 (MIC 16 uM), P.aeruginosa ATCC 27853 (MIC >512 uM), and C. albicans NCYC 1467 (MIC 4 uM). Also antibiofilms of S. aureus (MBIC/MBEC: 4/16 uM

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Candida albicans NCYC 1467

Source & Reference

Database Source NA

Other

Evidence Text

A (MIC 8 uM), E. coli NCTC 10418 (MIC 16 uM), P.aeruginosa ATCC 27853 (MIC >512 uM), and C. albicans NCYC 1467 (MIC 4 uM). Also antibiofilms of S. aureus (MBIC/MBEC: 4/16 uM), MRSA (MBIC/MBEC: 8/32 uM), and E. c

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism Staphylococcus aureus NCTC 10788 or MRSA NCTC 12493

Source & Reference

Database Source CAFPdb Antifungipept

Other

Evidence Text

active against S. aureus NCTC 10788 or MRSA NCTC 12493 (MIC 4 uM), MRSA B038 V1S1 A (MIC 8 uM), E. coli NCTC 10418 (MIC 16 uM), P.aeruginosa ATCC 27853 (MI

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16 µM

Target

Target Organism Escherichia coli NCTC 10418

Source & Reference

Database Source CAFPdb Antifungipept

Other

Evidence Text

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >512 µM

Target

Target Organism P.aeruginosa ATCC 27853

Source & Reference

Database Source CAFPdb Antifungipept

Other

Evidence Text

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism Candida albicans NCYC 1467

Source & Reference

Database Source CAFPdb Antifungipept

Other

Evidence Text

Evidence 9 Activity

Activity

Activity Endpoint 20% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 32 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

20% Hemolysis | 32 | µM | target cell: Horse erythrocytes

Target

Target Cell Horse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

A novel membrane-disruptive antimicrobial peptide from frog skin secretion against cystic fibrosis isolates and evaluation of anti-MRSA effect using Galleria mellonella model. | Biochim Biophys Acta | 2019

Evidence 10 Activity

Activity

Activity Endpoint 80% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 64 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

80% Hemolysis | 64 | µM | target cell: Horse erythrocytes

Target

Target Cell Horse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Evidence 11 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Biochim Biophys Acta Gen Subj. 2019 May 1863(5):849-856.

Evidence 12 Hemolysis

Source & Reference

source APD_complete PD_Hemolysis

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.