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Peptide record

TPDB13193

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB13193
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP PD_Hemolysis ToxinPred 3.0
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
FLSLIPKIAGGIAALVKNL
Physicochemical Analysis
C93H160N22O22
RDCEQHMTWY
L
1938.43
10.60
2
0
12
+2
-1.74
1.400
174.74
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
3
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
4
L
2
K
0
M
1
F
1
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 4 K: 2 M: 0 F: 1 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
19
C93H160N22O22
1938.43
10.60
+2
-1.74
1.400
Evidence Records 6 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
<8 µM
Hemolytic Cytotoxic
<5% Hemolysis | <8 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
A Novel Amphibian Antimicrobial Peptide, Phylloseptin-PV1, Exhibits Effective Anti- staphylococcal Activity Without Inducing Either Hepatic or Renal Toxicity in Mice. | Front Microbiol | 2020
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
50% Hemolysis | 32 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
A Novel Amphibian Antimicrobial Peptide, Phylloseptin-PV1, Exhibits Effective Anti- staphylococcal Activity Without Inducing Either Hepatic or Renal Toxicity in Mice. | Front Microbiol | 2020
Evidence 3 Activity

Activity

100% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
100% Hemolysis | 128 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
A Novel Amphibian Antimicrobial Peptide, Phylloseptin-PV1, Exhibits Effective Anti- staphylococcal Activity Without Inducing Either Hepatic or Renal Toxicity in Mice. | Front Microbiol | 2020
Evidence 4 Activity

Activity

IC50
Toxicity
230.3 µM
Cytotoxic
IC50 | 230.3 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
A Novel Amphibian Antimicrobial Peptide, Phylloseptin-PV1, Exhibits Effective Anti- staphylococcal Activity Without Inducing Either Hepatic or Renal Toxicity in Mice. | Front Microbiol | 2020
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Microbiol. 2020 Oct 26 11:565158.
Evidence 6 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis