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Peptide record

TPDB13187

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB13187
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
FLSLIPKIISAISALIKHF
Physicochemical Analysis
C104H171N23O23
RNDCEQGMTWYV
I
2111.64
10.60
3
0
12
+2
-2.05
1.479
174.74
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
5
I
3
L
2
K
0
M
2
F
1
P
3
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 5 L: 3 K: 2 M: 0 F: 2 P: 1 S: 3 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
19
C104H171N23O23
2111.64
10.60
+2
-2.05
1.479
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
1.074 µM
Hemolytic Cytotoxic
50% Hemolysis | 1.074 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship of an antimicrobial peptide, Phylloseptin-PHa: balance of hydrophobicity and charge determines the selectivity of bioactivities. | Drug Des Devel Ther | 2019
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
50 %
Hemolytic Cytotoxic
Hemolytic_activity: Horse erythrocytes:50% Hemolysis=1.074µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Drug Des Devel Ther. 2019 Jan 23 13:447-458
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis