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Peptide record

TPDB13183

Antibacterial Antifungal Toxicity standard

19 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB13183

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 19-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.

Sequence

LFNNYITAALKLLEKLYKV

FASTA

>TPDB13183|Antibacterial;Antifungal;Toxicity|length=19
LFNNYITAALKLLEKLYKV

Formula C109H176N24O27

Absent Amino Acids RDCQGHMPSW

Common Amino Acids L

Mass 2254.74

PI 9.89

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 12

Net Charge +2

Boman Index -0.42

Hydrophobicity 0.453

Aliphatic Index 148.95

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 2980

Absorbance 280nm 132.17

Polar Residues 5

number

Amino Acid Distribution

A: 2 R: 0 N: 2 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 1 L: 5 K: 3 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 2 V: 1

Length

Formula

C109H176N24O27

Mass

2254.74

9.89

Net Charge

Boman Index

-0.42

Hydrophobicity

0.453

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

active against S. aureus ATCC 25923 (MIC 4 uM), S. epidermidis (MIC 5.33 uM), fungi T. rubrum (MIC 32 uM), and C. albicans (MIC 8 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5.33 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against S. aureus ATCC 25923 (MIC 4 uM), S. epidermidis (MIC 5.33 uM), fungi T. rubrum (MIC 32 uM), and C. albicans (MIC 8 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32 µM

Target

Target Organism T. rubrum

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against S. aureus ATCC 25923 (MIC 4 uM), S. epidermidis (MIC 5.33 uM), fungi T. rubrum (MIC 32 uM), and C. albicans (MIC 8 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP

Other

Evidence Text

eus ATCC 25923 (MIC 4 uM), S. epidermidis (MIC 5.33 uM), fungi T. rubrum (MIC 32 uM), and C. albicans (MIC 8 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

active against S. aureus ATCC 25923 (MIC 4 uM), S. epidermidis (MIC 5.33 uM), fungi T. rubrum (MIC 32 uM), and C. albicans (MIC 8 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 5.33 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

active against S. aureus ATCC 25923 (MIC 4 uM), S. epidermidis (MIC 5.33 uM), fungi T. rubrum (MIC 32 uM), and C. albicans (MIC 8 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 32 µM

Target

Target Organism T. rubrum

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

active against S. aureus ATCC 25923 (MIC 4 uM), S. epidermidis (MIC 5.33 uM), fungi T. rubrum (MIC 32 uM), and C. albicans (MIC 8 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

eus ATCC 25923 (MIC 4 uM), S. epidermidis (MIC 5.33 uM), fungi T. rubrum (MIC 32 uM), and C. albicans (MIC 8 uM).

Evidence 9 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 64 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Intragenic antimicrobial peptides (IAPs) from human proteins with potent antimicrobial and anti-inflammatory activity. | PLoS One | 2019

Evidence 10 Activity

Activity

Activity Endpoint 10% Killing

Detail Source Activity Toxicity

Activity Measurement 10 µM

Toxicity Type Cytotoxic

Toxicity Raw

10% Killing | 10 | µM | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Intragenic antimicrobial peptides (IAPs) from human proteins with potent antimicrobial and anti-inflammatory activity. | PLoS One | 2019

Evidence 11 Activity

Activity

Activity Endpoint 80% Killing

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Cytotoxic

Toxicity Raw

80% Killing | 100 | µM | target cell: Murine peritoneal macrophages

Target

Target Cell Murine peritoneal macrophages

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Intragenic antimicrobial peptides (IAPs) from human proteins with potent antimicrobial and anti-inflammatory activity. | PLoS One | 2019