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Peptide record

TPDB13170

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB13170
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 dbACP AFP-GFuse Antifungipept CAFPdb dbAMP Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 19-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
FLSLIPHIASGIASLVKNF
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C97H155N23O24
RDCEQMTWY
ILS
2027.44
10.10
2
0
11
+1
-0.90
1.226
148.95
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
4
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
1
H
3
I
3
L
1
K
0
M
2
F
1
P
3
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 3 L: 3 K: 1 M: 0 F: 2 P: 1 S: 3 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
19 reviewed residue count
C97H155N23O24 sequence-only estimate (linear, free termini)
2027.44 sequence-only estimate (linear, free termini)
10.10 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
-0.90 sequence-only estimate (linear, free termini)
1.226 sequence-only estimate (linear, free termini)
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus (MIC 5 uM), C. albicans (MIC 20 uM), and E.coli (200 uM). It also exhibited anticancer activity, inc
Evidence 2 Activity

Activity

MIC
Antibacterial
20 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

Active against S. aureus (MIC 5 uM), C. albicans (MIC 20 uM), and E.coli (200 uM). It also exhibited anticancer activity, including the human metastat
Evidence 3 Activity

Activity

MIC
Antifungal
5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus (MIC 5 uM), C. albicans (MIC 20 uM), and E.coli (200 uM). It also exhibited anticancer activity, inc
Evidence 4 Activity

Activity

MIC
Antifungal
20 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 5 uM), C. albicans (MIC 20 uM), and E.coli (200 uM). It also exhibited anticancer activity, including the human metastat
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
18.6 µM
Hemolytic Cytotoxic
50% Hemolysis | 18.6 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Phylloseptin-PBa1, -PBa2, -PBa3: Three novel antimicrobial peptides from the skin secretion of Burmeister's leaf frog (Phyllomedusa burmeisteri). | Biochem Biophys Res Commun | 2019
Evidence 6 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2019 Feb 12 509(3):664-673.
Evidence 7 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis