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Peptide record

TPDB13159

Antibacterial Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB13159
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 19-aa standard-residue multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
GLLKKIAKKAKKAGKKLGY
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C96H175N27O21
RNDCEQHMFPSTWV
K
2043.61
11.02
8
0
8
+8
0.87
-0.653
97.89
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
0.73
1
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
3
L
8
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 3 K: 8 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
19 reviewed residue count
C96H175N27O21 sequence-only estimate (linear, free termini)
2043.61 sequence-only estimate (linear, free termini)
11.02 sequence-only estimate (linear, free termini)
+8 sequence-only estimate (linear, free termini)
0.87 sequence-only estimate (linear, free termini)
-0.653 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
10% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alpha-helical antimicrobial peptides--using a sequence template to guide structure-activity relationship studies. | Biochim Biophys Acta | 2006
Evidence 2 Activity

Activity

20% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
20% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alpha-helical antimicrobial peptides--using a sequence template to guide structure-activity relationship studies. | Biochim Biophys Acta | 2006
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis