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Peptide record

TPDB13156

Antibacterial Anticancer Antifungal Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB13156
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 ToxinPred 3.0
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
GIFDVLKNLAKGVITSLAS
Physicochemical Analysis
C89H152N22O26
RCEQHMPWY
L
1946.32
9.88
2
1
10
+1
0.42
0.911
143.68
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
2
A
0
R
1
N
1
D
0
C
0
E
0
Q
2
G
0
H
2
I
3
L
2
K
0
M
1
F
0
P
2
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 3 K: 2 M: 0 F: 1 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
19
C89H152N22O26
1946.32
9.88
+1
0.42
0.911
Evidence Records 31 records
Evidence 1 Activity

Activity

MIC
Antibacterial
62.5 µM

Target

Klebsiella pneumoniae ATCC 49472 or ATCC BAA-2814

Source & Reference

NA

Other

Active against antibiotic-resistant K. pneumoniae ATCC 49472 or ATCC BAA-2814 (MIC 62.5 uM) and reference strains of E. coli ATCC 35218 (MIC 31.25 uM), P. aeruginosa ATCC 27853 (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
31.25 µM

Target

Escherichia coli ATCC 35218

Source & Reference

NA

Other

esistant K. pneumoniae ATCC 49472 or ATCC BAA-2814 (MIC 62.5 uM) and reference strains of E. coli ATCC 35218 (MIC 31.25 uM), P. aeruginosa ATCC 27853 (MIC 62.5 uM), S. typhimurium ATCC 14028 (MIC 62.5 uM), Gram+ S
Evidence 3 Activity

Activity

MIC
Antibacterial
62.5 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

NA

Other

r ATCC BAA-2814 (MIC 62.5 uM) and reference strains of E. coli ATCC 35218 (MIC 31.25 uM), P. aeruginosa ATCC 27853 (MIC 62.5 uM), S. typhimurium ATCC 14028 (MIC 62.5 uM), Gram+ S. aureus ATCC 12600 or ATCC 25923 or ATC
Evidence 4 Activity

Activity

MIC
Antibacterial
62.5 µM

Target

S. typhimurium ATCC 14028

Source & Reference

NA

Other

nce strains of E. coli ATCC 35218 (MIC 31.25 uM), P. aeruginosa ATCC 27853 (MIC 62.5 uM), S. typhimurium ATCC 14028 (MIC 62.5 uM), Gram+ S. aureus ATCC 12600 or ATCC 25923 or ATCC BAA-2312 (MIC 12.5-31.25 uM), E. faeciu
Evidence 5 Activity

Activity

MIC
Antibacterial
12.5-31.25 µM

Target

Staphylococcus aureus ATCC 12600 or ATCC 25923 or ATCC BAA-2312

Source & Reference

NA

Other

), P. aeruginosa ATCC 27853 (MIC 62.5 uM), S. typhimurium ATCC 14028 (MIC 62.5 uM), Gram+ S. aureus ATCC 12600 or ATCC 25923 or ATCC BAA-2312 (MIC 12.5-31.25 uM), E. faecium ATCC 19434 (MIC 62.5 uM), and E.faecalis ATCC 51299 (MIC 250 uM). Also, activ
Evidence 6 Activity

Activity

MIC
Antibacterial
62.5 µM

Target

E. faecium ATCC 19434

Source & Reference

NA

Other

62.5 uM), Gram+ S. aureus ATCC 12600 or ATCC 25923 or ATCC BAA-2312 (MIC 12.5-31.25 uM), E. faecium ATCC 19434 (MIC 62.5 uM), and E.faecalis ATCC 51299 (MIC 250 uM). Also, active against E. coli ATCC 25922 (MIC 6.2
Evidence 7 Activity

Activity

MIC
Antibacterial
250 µM

Target

Enterococcus faecalis ATCC 51299

Source & Reference

NA

Other

ATCC 25923 or ATCC BAA-2312 (MIC 12.5-31.25 uM), E. faecium ATCC 19434 (MIC 62.5 uM), and E.faecalis ATCC 51299 (MIC 250 uM). Also, active against E. coli ATCC 25922 (MIC 6.25 uM), P. aeruginosa ATCC 27853 (MIC 25
Evidence 8 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

um ATCC 19434 (MIC 62.5 uM), and E.faecalis ATCC 51299 (MIC 250 uM). Also, active against E. coli ATCC 25922 (MIC 6.25 uM), P. aeruginosa ATCC 27853 (MIC 25 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), Gram+ S. au
Evidence 9 Activity

Activity

MIC
Antibacterial
25 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

NA

Other

.faecalis ATCC 51299 (MIC 250 uM). Also, active against E. coli ATCC 25922 (MIC 6.25 uM), P. aeruginosa ATCC 27853 (MIC 25 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), Gram+ S. aureus ATCC 25923 (MIC 12.5 uM), S. epid
Evidence 10 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

A. baumannii ATCC 19606

Source & Reference

NA

Other

o, active against E. coli ATCC 25922 (MIC 6.25 uM), P. aeruginosa ATCC 27853 (MIC 25 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), Gram+ S. aureus ATCC 25923 (MIC 12.5 uM), S. epidermidis ATCC 12228 (MIC 6.25 uM), B. me
Evidence 11 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

NA

Other

5 uM), P. aeruginosa ATCC 27853 (MIC 25 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), Gram+ S. aureus ATCC 25923 (MIC 12.5 uM), S. epidermidis ATCC 12228 (MIC 6.25 uM), B. megaterium BM11 (MIC 0.78 uM), and a strain
Evidence 12 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

NA

Other

25 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), Gram+ S. aureus ATCC 25923 (MIC 12.5 uM), S. epidermidis ATCC 12228 (MIC 6.25 uM), B. megaterium BM11 (MIC 0.78 uM), and a strain of the major emerging yeast pathogen C. p
Evidence 13 Activity

Activity

MIC
Antibacterial
0.78 µM

Target

B. megaterium BM11

Source & Reference

NA

Other

5 uM), Gram+ S. aureus ATCC 25923 (MIC 12.5 uM), S. epidermidis ATCC 12228 (MIC 6.25 uM), B. megaterium BM11 (MIC 0.78 uM), and a strain of the major emerging yeast pathogen C. parapsilosis ATCC 22019 (MIC 25 uM)
Evidence 14 Activity

Activity

MIC
Antibacterial
25 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

NA

Other

uM), B. megaterium BM11 (MIC 0.78 uM), and a strain of the major emerging yeast pathogen C. parapsilosis ATCC 22019 (MIC 25 uM) ( Conlon et al., 2022 .
Evidence 15 Activity

Activity

MIC
Antifungal
62.5 µM

Target

Klebsiella pneumoniae ATCC 49472 or ATCC BAA-2814

Source & Reference

NA

Other

Active against antibiotic-resistant K. pneumoniae ATCC 49472 or ATCC BAA-2814 (MIC 62.5 uM) and reference strains of E. coli ATCC 35218 (MIC 31.25 uM), P. aeruginosa ATCC 27853 (MIC
Evidence 16 Activity

Activity

MIC
Antifungal
31.25 µM

Target

Escherichia coli ATCC 35218

Source & Reference

NA

Other

esistant K. pneumoniae ATCC 49472 or ATCC BAA-2814 (MIC 62.5 uM) and reference strains of E. coli ATCC 35218 (MIC 31.25 uM), P. aeruginosa ATCC 27853 (MIC 62.5 uM), S. typhimurium ATCC 14028 (MIC 62.5 uM), Gram+ S
Evidence 17 Activity

Activity

MIC
Antifungal
62.5 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

NA

Other

r ATCC BAA-2814 (MIC 62.5 uM) and reference strains of E. coli ATCC 35218 (MIC 31.25 uM), P. aeruginosa ATCC 27853 (MIC 62.5 uM), S. typhimurium ATCC 14028 (MIC 62.5 uM), Gram+ S. aureus ATCC 12600 or ATCC 25923 or ATC
Evidence 18 Activity

Activity

MIC
Antifungal
62.5 µM

Target

S. typhimurium ATCC 14028

Source & Reference

NA

Other

nce strains of E. coli ATCC 35218 (MIC 31.25 uM), P. aeruginosa ATCC 27853 (MIC 62.5 uM), S. typhimurium ATCC 14028 (MIC 62.5 uM), Gram+ S. aureus ATCC 12600 or ATCC 25923 or ATCC BAA-2312 (MIC 12.5-31.25 uM), E. faeciu
Evidence 19 Activity

Activity

MIC
Antifungal
12.5-31.25 µM

Target

Staphylococcus aureus ATCC 12600 or ATCC 25923 or ATCC BAA-2312

Source & Reference

NA

Other

), P. aeruginosa ATCC 27853 (MIC 62.5 uM), S. typhimurium ATCC 14028 (MIC 62.5 uM), Gram+ S. aureus ATCC 12600 or ATCC 25923 or ATCC BAA-2312 (MIC 12.5-31.25 uM), E. faecium ATCC 19434 (MIC 62.5 uM), and E.faecalis ATCC 51299 (MIC 250 uM). Also, activ
Evidence 20 Activity

Activity

MIC
Antifungal
62.5 µM

Target

E. faecium ATCC 19434

Source & Reference

NA

Other

62.5 uM), Gram+ S. aureus ATCC 12600 or ATCC 25923 or ATCC BAA-2312 (MIC 12.5-31.25 uM), E. faecium ATCC 19434 (MIC 62.5 uM), and E.faecalis ATCC 51299 (MIC 250 uM). Also, active against E. coli ATCC 25922 (MIC 6.2
Evidence 21 Activity

Activity

MIC
Antifungal
250 µM

Target

Enterococcus faecalis ATCC 51299

Source & Reference

NA

Other

ATCC 25923 or ATCC BAA-2312 (MIC 12.5-31.25 uM), E. faecium ATCC 19434 (MIC 62.5 uM), and E.faecalis ATCC 51299 (MIC 250 uM). Also, active against E. coli ATCC 25922 (MIC 6.25 uM), P. aeruginosa ATCC 27853 (MIC 25
Evidence 22 Activity

Activity

MIC
Antifungal
6.25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

um ATCC 19434 (MIC 62.5 uM), and E.faecalis ATCC 51299 (MIC 250 uM). Also, active against E. coli ATCC 25922 (MIC 6.25 uM), P. aeruginosa ATCC 27853 (MIC 25 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), Gram+ S. au
Evidence 23 Activity

Activity

MIC
Antifungal
25 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

NA

Other

.faecalis ATCC 51299 (MIC 250 uM). Also, active against E. coli ATCC 25922 (MIC 6.25 uM), P. aeruginosa ATCC 27853 (MIC 25 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), Gram+ S. aureus ATCC 25923 (MIC 12.5 uM), S. epid
Evidence 24 Activity

Activity

MIC
Antifungal
6.25 µM

Target

A. baumannii ATCC 19606

Source & Reference

NA

Other

o, active against E. coli ATCC 25922 (MIC 6.25 uM), P. aeruginosa ATCC 27853 (MIC 25 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), Gram+ S. aureus ATCC 25923 (MIC 12.5 uM), S. epidermidis ATCC 12228 (MIC 6.25 uM), B. me
Evidence 25 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

NA

Other

5 uM), P. aeruginosa ATCC 27853 (MIC 25 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), Gram+ S. aureus ATCC 25923 (MIC 12.5 uM), S. epidermidis ATCC 12228 (MIC 6.25 uM), B. megaterium BM11 (MIC 0.78 uM), and a strain
Evidence 26 Activity

Activity

MIC
Antifungal
6.25 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

NA

Other

25 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), Gram+ S. aureus ATCC 25923 (MIC 12.5 uM), S. epidermidis ATCC 12228 (MIC 6.25 uM), B. megaterium BM11 (MIC 0.78 uM), and a strain of the major emerging yeast pathogen C. p
Evidence 27 Activity

Activity

MIC
Antifungal
0.78 µM

Target

B. megaterium BM11

Source & Reference

NA

Other

5 uM), Gram+ S. aureus ATCC 25923 (MIC 12.5 uM), S. epidermidis ATCC 12228 (MIC 6.25 uM), B. megaterium BM11 (MIC 0.78 uM), and a strain of the major emerging yeast pathogen C. parapsilosis ATCC 22019 (MIC 25 uM)
Evidence 28 Activity

Activity

MIC
Antifungal
25 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

NA

Other

uM), B. megaterium BM11 (MIC 0.78 uM), and a strain of the major emerging yeast pathogen C. parapsilosis ATCC 22019 (MIC 25 uM) ( Conlon et al., 2022 .
Evidence 29 Activity

Activity

50% Hemolysis
Toxicity
98 µM
Hemolytic Cytotoxic
50% Hemolysis | 98 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Peptidomic Analysis of Skin Secretions of the Caribbean Frogs Leptodactylus insularum and Leptodactylus nesiotus (Leptodactylidae) Identifies an Ocellatin with Broad | Antibiotics (Basel) | 2020
Evidence 30 Activity

Activity

LC50
Toxicity
48±9 µM
Cytotoxic
LC50 | 48±9 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Antimicrobial, cytotoxic, and insulin-releasing activities of the amphibian host-defense peptide ocellatin-3N and its L-lysine-substituted analogs. | J Pept Sci | 2022
Evidence 31 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2023 Apr 29(4):e3463.