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Peptide record

TPDB13127

Antibacterial Antifungal Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB13127
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KLKKLLKKWLKLLKKLLK
Physicochemical Analysis
C113H208N28O19
ARNDCEQGHIMFPSTYV
K
2263.07
11.41
9
0
9
+9
2.58
-0.311
173.33
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
243.03
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
8
L
9
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 8 K: 9 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
18
C113H208N28O19
2263.07
11.41
+9
2.58
-0.311
Evidence Records 16 records
Evidence 1 Activity

Activity

HC50
Hemolysis
14 µM
[Ref.20363271]HC50=14 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Peptides. 2010 Jul 31(7):1251-61.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

HC50
Hemolysis
150 µM
[Ref.20363271]HC50=150 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Peptides. 2010 Jul 31(7):1251-61.
Evidence 3 Activity

Activity

HC50
Hemolysis
116 µM
[Ref.20363271]HC50=116 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Peptides. 2010 Jul 31(7):1251-61.
Evidence 4 Activity

Activity

HC50
Hemolysis
800 µM
[Ref.20363271]HC50>800 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Peptides. 2010 Jul 31(7):1251-61.
Evidence 5 Activity

Activity

HC50
Hemolysis
154 µM
[Ref.20363271]HC50=154 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Peptides. 2010 Jul 31(7):1251-61.
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
14 µM
Hemolytic Cytotoxic
50% Hemolysis | 14 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 7 Activity

Activity

HC50
Toxicity
14 µM
Hemolytic
Hemolytic_activity: [Ref.20363271]HC50=14 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2010 Jul 31(7):1251-61.
Evidence 8 Activity

Activity

HC50
Toxicity
150 µM
Hemolytic
Hemolytic_activity: [Ref.20363271]HC50=150 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2010 Jul 31(7):1251-61.
Evidence 9 Activity

Activity

HC50
Toxicity
116 µM
Hemolytic
Hemolytic_activity: [Ref.20363271]HC50=116 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2010 Jul 31(7):1251-61.
Evidence 10 Activity

Activity

HC50
Toxicity
800 µM
Hemolytic
Hemolytic_activity: [Ref.20363271]HC50>800 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2010 Jul 31(7):1251-61.
Evidence 11 Activity

Activity

HC50
Toxicity
154 µM
Hemolytic
Hemolytic_activity: [Ref.20363271]HC50=154 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2010 Jul 31(7):1251-61.
Evidence 12 Hemolysis

Activity

14 µM
HC50
[Ref.20363271]HC50=14 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

HemoPI PD_Hemolysis
Peptides. 2010 Jul 31(7):1251-61.
DRAMP4
PD_Hemolysis
Evidence 13 Hemolysis

Activity

150 µM
HC50
[Ref.20363271]HC50=150 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

HemoPI PD_Hemolysis
Peptides. 2010 Jul 31(7):1251-61.
DRAMP4
PD_Hemolysis
Evidence 14 Hemolysis

Activity

116 µM
HC50
[Ref.20363271]HC50=116 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

HemoPI PD_Hemolysis
Peptides. 2010 Jul 31(7):1251-61.
DRAMP4
PD_Hemolysis
Evidence 15 Hemolysis

Activity

800 µM
HC50
[Ref.20363271]HC50>800 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

HemoPI PD_Hemolysis
Peptides. 2010 Jul 31(7):1251-61.
DRAMP4
PD_Hemolysis
Evidence 16 Hemolysis

Activity

154 µM
HC50
[Ref.20363271]HC50=154 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

HemoPI PD_Hemolysis
Peptides. 2010 Jul 31(7):1251-61.
DRAMP4
PD_Hemolysis