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Peptide record

TPDB13126

Antibacterial Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB13126
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 18-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
WLSKTAKKLWLSKTAKKL
Physicochemical Analysis
C102H172N26O23
RNDCEQGHIMFPYV
K
2130.65
11.21
6
0
8
+6
0.20
-0.522
97.78
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
11000
516.27
4
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
6
K
0
M
0
F
0
P
2
S
2
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 6 M: 0 F: 0 P: 0 S: 2 T: 2 W: 2 Y: 0 V: 0
Chemical Descriptors
18
C102H172N26O23
2130.65
11.21
+6
0.20
-0.522
Evidence Records 4 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
5% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial activities and molecular mechanism of amino-terminal fragments from pig nematode antimicrobial peptide CP-1. | Chem Biol Drug Des | 2018
Evidence 2 Activity

Activity

10% Killing
Toxicity
64 µM
Cytotoxic
10% Killing | 64 | µM | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
Antibacterial activities and molecular mechanism of amino-terminal fragments from pig nematode antimicrobial peptide CP-1. | Chem Biol Drug Des | 2018
Evidence 3 Activity

Activity

25% Killing
Toxicity
128 µM
Cytotoxic
25% Killing | 128 | µM | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
Antibacterial activities and molecular mechanism of amino-terminal fragments from pig nematode antimicrobial peptide CP-1. | Chem Biol Drug Des | 2018
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.29266746] MHC5>128 µM against human red blood cells | Cytotoxicity: [Ref.29266746] The cell viability of IPEC-J2 cells induced by WL2 is 99.0%, 95.0%, 89%, 89.8%, 85.2%, 86.8% and 75.1% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 µM. The cell viability of IPEC-J2 cells induced by the control Melittin is 77.

Target

erythrocytes

Source & Reference

NA
DRAMP
Chem Biol Drug Des. 2018 May 91(5):1017-1029. doi: 10.1111/cbdd.13165.