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Peptide record

TPDB13123

Antibacterial Anticancer Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB13123
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ITEVITILLNRLTDRLEK
Physicochemical Analysis
C95H170N26O29
ACQGHMFPSWY
L
2140.55
7.13
3
3
8
+0
5.62
0.217
167.78
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
4
Residue Composition
number
0
A
2
R
1
N
1
D
0
C
2
E
0
Q
0
G
0
H
3
I
4
L
1
K
0
M
0
F
0
P
0
S
3
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 1 C: 0 E: 2 Q: 0 G: 0 H: 0 I: 3 L: 4 K: 1 M: 0 F: 0 P: 0 S: 0 T: 3 W: 0 Y: 0 V: 1
Chemical Descriptors
18
C95H170N26O29
2140.55
7.13
+0
5.62
0.217
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>250 µM
Hemolytic Cytotoxic
50% Hemolysis | >250 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Helminth Defense Molecules as Design Templates for Membrane Active Antibiotics. | ACS Infect Dis | 2019
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
5 %
Hemolytic
Hemolytic_activity: [Ref.31117348] 5% hemolysis at 250 µM against human blood cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Infect Dis. 2019 May 30. doi: 10.1021/acsinfecdis.9b00157.