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Peptide record

TPDB13121

Antibacterial Antifungal Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB13121
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
LKMLGMLFHNIRNILKTV
Physicochemical Analysis
C98H169N27O22S2
ADCEQPSWY
L
2141.71
11.64
4
0
10
+3
0.36
0.633
146.11
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
0
A
1
R
2
N
0
D
0
C
0
E
0
Q
1
G
1
H
2
I
4
L
2
K
2
M
1
F
0
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 2 L: 4 K: 2 M: 2 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
18
C98H169N27O22S2
2141.71
11.64
+3
0.36
0.633
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
128 µM

Target

S.aureus ATCC 25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
weakly active against S.aureus ATCC 25923 (MIC 128 uM), S. epidermidis (MIC 64 uM), and C. albicans (MIC 64 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
64 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP

Other

weakly active against S.aureus ATCC 25923 (MIC 128 uM), S. epidermidis (MIC 64 uM), and C. albicans (MIC 64 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
64 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

weakly active against S.aureus ATCC 25923 (MIC 128 uM), S. epidermidis (MIC 64 uM), and C. albicans (MIC 64 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
128 µM

Target

S.aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
weakly active against S.aureus ATCC 25923 (MIC 128 uM), S. epidermidis (MIC 64 uM), and C. albicans (MIC 64 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
64 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

weakly active against S.aureus ATCC 25923 (MIC 128 uM), S. epidermidis (MIC 64 uM), and C. albicans (MIC 64 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
64 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

weakly active against S.aureus ATCC 25923 (MIC 128 uM), S. epidermidis (MIC 64 uM), and C. albicans (MIC 64 uM).
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
50% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Intragenic antimicrobial peptides (IAPs) from human proteins with potent antimicrobial and anti-inflammatory activity. | PLoS One | 2019
Evidence 8 Activity

Activity

10% Killing
Toxicity
10 µM
Cytotoxic
10% Killing | 10 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Intragenic antimicrobial peptides (IAPs) from human proteins with potent antimicrobial and anti-inflammatory activity. | PLoS One | 2019
Evidence 9 Activity

Activity

80% Killing
Toxicity
100 µM
Cytotoxic
80% Killing | 100 | µM | target cell: Murine peritoneal macrophages

Target

Murine peritoneal macrophages

Source & Reference

NA
DBAASP
Intragenic antimicrobial peptides (IAPs) from human proteins with potent antimicrobial and anti-inflammatory activity. | PLoS One | 2019