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Peptide record

TPDB13103

L4 Antibacterial Anticancer standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB13103
L4
Antibacterial Anticancer
Anti-infective peptides Cancer-related peptides
AntiBP3 Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab
standard
No
A 18-aa standard-residue multi-activity (Antibacterial and Anticancer) peptide sequence curated from AntiBP3, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.
Sequence
PAWFKARRWAWRMLKKAA
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C109H165N33O19S1
NDCEQGHISTYV
A
2273.78
12.71
6
0
11
+6
1.95
-0.667
49.44
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
16500
7.26
0
Residue Composition
number
5
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
3
K
1
M
1
F
1
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 5 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 3 M: 1 F: 1 P: 1 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
18 reviewed residue count
C109H165N33O19S1 sequence-only estimate (linear, free termini)
2273.78 sequence-only estimate (linear, free termini)
12.71 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
1.95 sequence-only estimate (linear, free termini)
-0.667 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Cyclic Activity
Free Activity
Antimicrobial Activity
Lactoferrin Activity
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
IC50=31 µM
Anticancer
31 µM

Target

Skin Cancer
Meth A
Skin

Assay & Model

MTT/MTS assay
4-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2002

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50=16 µM
Anticancer
16 µM

Target

Breast Cancer
MT-1
Breast

Assay & Model

MTT/MTS assay
4-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2002
Evidence 3 Activity

Activity

IC50
IC50=57 µM
Anticancer
57 µM

Target

Colon Cancer
HT-29
Colon

Assay & Model

MTT/MTS assay
4-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2002