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Peptide record

TPDB13090

Antibacterial Anticancer Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB13090
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 18-aa standard-residue multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
QLGRRRHRRRPSRRRRHW
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C104H180N54O21
ANDCEIKMFTYV
R
2522.92
13.35
12
0
2
+10
8.85
-3.044
21.67
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
5500
2.18
2
Residue Composition
number
0
A
10
R
0
N
0
D
0
C
0
E
1
Q
1
G
2
H
0
I
1
L
0
K
0
M
0
F
1
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 2 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
18 reviewed residue count
C104H180N54O21 sequence-only estimate (linear, free termini)
2522.92 sequence-only estimate (linear, free termini)
13.35 sequence-only estimate (linear, free termini)
+10 sequence-only estimate (linear, free termini)
8.85 sequence-only estimate (linear, free termini)
-3.044 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
HEXIM1 Peptide Exhibits Antimicrobial Activity Against Antibiotic Resistant Bacteria Through Guidance of Cell Penetrating Peptide. | Front Microbiol | 2019
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: HaCat: Not active up to 100 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Oncotarget. 2016 Feb 2 7(5):5483-94.