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Peptide record

TPDB13087

Antibacterial Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB13087
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 18-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
AAWKKAAKKAAKSAKKAG
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C82H144N26O20
RNDCEQHILMFPTYV
A
1814.21
11.29
7
0
9
+7
1.36
-0.833
44.44
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
3.03
1
Residue Composition
number
8
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
7
K
0
M
0
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 8 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 7 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
18 reviewed residue count
C82H144N26O20 sequence-only estimate (linear, free termini)
1814.21 sequence-only estimate (linear, free termini)
11.29 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
1.36 sequence-only estimate (linear, free termini)
-0.833 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
0% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effect of Non-natural Hydrophobic Amino Acids on the Efficacy and Properties of the Antimicrobial Peptide C18G. | Probiotics Antimicrob Proteins | 2020