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Peptide record

TPDB13084

Antibacterial Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB13084
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 18-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
VLLRALARKILLGIKKYG
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C96H173N27O20
NDCEQHMFPSTW
L
2025.60
11.59
5
0
11
+5
0.15
0.722
178.89
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
1490
0.74
1
Residue Composition
number
2
A
2
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
5
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 5 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
18 reviewed residue count
C96H173N27O20 sequence-only estimate (linear, free termini)
2025.60 sequence-only estimate (linear, free termini)
11.59 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
0.15 sequence-only estimate (linear, free termini)
0.722 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

92% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
92% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Designing Antibacterial Peptides with Enhanced Killing Kinetics. | Front Microbiol | 2018