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Peptide record

TPDB13069

Antibacterial Anticancer Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB13069
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 18-aa standard-residue multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
KWCFRVCYRGICYRKCRG
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C101H157N33O21S4
ANDEQHLMPST
RC
2297.81
10.00
6
0
6
+6
2.77
-0.478
37.78
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
8730
3.80
6
Residue Composition
number
0
A
4
R
0
N
0
D
4
C
0
E
0
Q
2
G
0
H
1
I
0
L
2
K
0
M
1
F
0
P
0
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 2 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
18 reviewed residue count
C101H157N33O21S4 sequence-only estimate (linear, free termini)
2297.81 sequence-only estimate (linear, free termini)
10.00 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
2.77 sequence-only estimate (linear, free termini)
-0.478 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
50% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of Tachyplesin Peptides and Their Cyclized Analogues to Improve Antimicrobial and Anticancer Properties. | Int J Mol Sci | 2019
Evidence 2 Activity

Activity

50% Cell death
Toxicity
7.5±0.3 µM
Cytotoxic
50% Cell death | 7.5±0.3 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Characterization of Tachyplesin Peptides and Their Cyclized Analogues to Improve Antimicrobial and Anticancer Properties. | Int J Mol Sci | 2019
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2019 Aug 26 20(17):4185.