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Peptide record

TPDB13056

Antibacterial Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB13056
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 17-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
PIHRRIPPRWPRLKRRW
Physicochemical Analysis
C108H174N40O18
ANDCEQGMFSTYV
R
2320.83
13.10
8
0
5
+7
3.73
-1.735
68.82
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
11000
473.97
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
2
I
1
L
1
K
0
M
0
F
4
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 2 L: 1 K: 1 M: 0 F: 0 P: 4 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
17
C108H174N40O18
2320.83
13.10
+7
3.73
-1.735
Evidence Records 4 records
Evidence 1 Activity

Activity

<=5% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
<=5% Hemolysis | 512 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018
Evidence 2 Activity

Activity

0% Killing
Toxicity
512 µg/mL
Cytotoxic
0% Killing | 512 | µg/mL | target cell: Murine dendritic cells JAWS II

Target

Murine dendritic cells JAWS II

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018
Evidence 3 Activity

Activity

0% Killing
Toxicity
<256 µg/mL
Cytotoxic
0% Killing | <256 | µg/mL | target cell: Chinese hamster ovary cells CHO-K1

Target

Chinese hamster ovary cells CHO-K1

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018
Evidence 4 Activity

Activity

20% Killing
Toxicity
512 µg/mL
Cytotoxic
20% Killing | 512 | µg/mL | target cell: Chinese hamster ovary cells CHO-K1

Target

Chinese hamster ovary cells CHO-K1

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018