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Peptide record

TPDB13054

Antibacterial Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB13054
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 17-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
CALKLTKAKRLVRKIGF
Physicochemical Analysis
C89H161N27O19S1
NDEQHMPSWY
K
1945.49
11.63
6
0
8
+6
2.10
0.194
120.59
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
2
R
0
N
0
D
1
C
0
E
0
Q
1
G
0
H
1
I
3
L
4
K
0
M
1
F
0
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 3 K: 4 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C89H161N27O19S1
1945.49
11.63
+6
2.10
0.194
Evidence Records 4 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Bovine erythrocytes

Target

Bovine erythrocytes

Source & Reference

NA
DBAASP
New Synthetic Peptides Conjugated to Gold Nanoclusters: Antibiotic Activity Against Escherichia coli O157:H7 and Methicillin-Resistant Staphylococcus aureus (MRSA). | Protein J | 2019
Evidence 2 Activity

Activity

<10% Cytotoxicity
Toxicity
50 µM
Cytotoxic
<10% Cytotoxicity | 50 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
New Synthetic Peptides Conjugated to Gold Nanoclusters: Antibiotic Activity Against Escherichia coli O157:H7 and Methicillin-Resistant Staphylococcus aureus (MRSA). | Protein J | 2019
Evidence 3 Activity

Activity

22% Cytotoxicity
Toxicity
100 µM
Cytotoxic
22% Cytotoxicity | 100 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
New Synthetic Peptides Conjugated to Gold Nanoclusters: Antibiotic Activity Against Escherichia coli O157:H7 and Methicillin-Resistant Staphylococcus aureus (MRSA). | Protein J | 2019
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31119600] No hemolytic activity against bovine blood cells | Cytotoxicity: [Ref.31119600] The cell viability of Vero ATCC CCL 1-81 cells induced by NBC2254 is 93.7%, 90.1%, 89.5%, 95.9% and 78.6% at peptide concentrations of 1.2, 3.7, 11.1, 33.3 and 100 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Protein J. 2019 May 22. doi: 10.1007/s10930-019-09840-9.