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Peptide record

TPDB13051

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB13051
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb dbAMP 3.0 i2APP PD_Hemolysis
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FFKLIPKLVKKLIKAFK
Physicochemical Analysis
C106H177N23O18
RNDCEQGHMSTWY
K
2061.71
11.21
6
0
10
+6
0.60
0.576
137.65
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
3
L
6
K
0
M
3
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 3 K: 6 M: 0 F: 3 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C106H177N23O18
2061.71
11.21
+6
0.60
0.576
Evidence Records 4 records
Evidence 1 Activity

Activity

11.2% Hemolysis
Toxicity
9.4 µM
Hemolytic Cytotoxic
11.2% Hemolysis | 9.4 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent and Broad-Spectrum Antimicrobial Activity of Analogs from the Scorpion Peptide Stigmurin. | Int J Mol Sci | 2019
Evidence 2 Activity

Activity

65% Hemolysis
Toxicity
75 µM
Hemolytic Cytotoxic
65% Hemolysis | 75 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent and Broad-Spectrum Antimicrobial Activity of Analogs from the Scorpion Peptide Stigmurin. | Int J Mol Sci | 2019
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
1 %
Hemolytic
Hemolytic_activity: [Ref.30709056] 1% hemolysis at 1.2 µg/ml , 6% hemolysis at 2.3 µg/ml , 10% hemolysis at 4.7 µg/ml , 12 % hemolysis at 9.4 µg/ml , 23% hemolysis at 18.8 µg/ml , 45% hemolysis at 37.5 µg/ml , 65% hemolysis at 75 µg/ml , 70% hemolysis at 150 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2019 Jan 31 20(3). pii: E623. doi: 10.3390/ijms20030623.
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis