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Peptide record

TPDB13048

Antibacterial Antifungal Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB13048
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
RFCWKVCYKGICFKKCK
Physicochemical Analysis
C99H154N26O19S4
ANDEQHLMPST
K
2140.71
9.92
6
0
6
+6
-0.48
-0.135
40.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
7240
338.20
5
Residue Composition
number
0
A
1
R
0
N
0
D
4
C
0
E
0
Q
1
G
0
H
1
I
0
L
5
K
0
M
2
F
0
P
0
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 5 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
17
C99H154N26O19S4
2140.71
9.92
+6
-0.48
-0.135
Evidence Records 6 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 32 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evaluation of the Antimicrobial Peptide, RP557, for the Broad-Spectrum Treatment of Wound Pathogens and Biofilm. | Front Microbiol | 2019
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evaluation of the Antimicrobial Peptide, RP557, for the Broad-Spectrum Treatment of Wound Pathogens and Biofilm. | Front Microbiol | 2019
Evidence 3 Activity

Activity

20% Cell death
Toxicity
256 µg/mL
Cytotoxic
20% Cell death | 256 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Evaluation of the Antimicrobial Peptide, RP557, for the Broad-Spectrum Treatment of Wound Pathogens and Biofilm. | Front Microbiol | 2019
Evidence 4 Activity

Activity

20% Cell death
Toxicity
64 µg/mL
Cytotoxic
20% Cell death | 64 | µg/mL | target cell: Mouse fibroblasts L929

Target

Mouse fibroblasts L929

Source & Reference

NA
DBAASP
Evaluation of the Antimicrobial Peptide, RP557, for the Broad-Spectrum Treatment of Wound Pathogens and Biofilm. | Front Microbiol | 2019
Evidence 5 Activity

Activity

10% Cell death
Toxicity
287 µg/mL
Cytotoxic
10% Cell death | 287 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Designed Antimicrobial Peptides for Recurrent Vulvovaginal Candidiasis Treatment. | Antimicrob Agents Chemother | 2019
Evidence 6 Activity

Activity

50% Cell death
Toxicity
281 µg/mL
Cytotoxic
50% Cell death | 281 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Designed Antimicrobial Peptides for Topical Treatment of Antibiotic Resistant Acne Vulgaris. | Antibiotics (Basel) | 2020