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Peptide record

TPDB13042

Antibacterial Cell-penetrating Peptides Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB13042
Antibacterial Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia CPPsite3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Cell-penetrating Peptides, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWCFRVCYRGSCYRRCR
Physicochemical Analysis
C96H148N34O21S4
ANDEQHILMPT
R
2242.69
10.10
6
0
5
+6
-0.57
-0.829
17.06
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
8730
389.27
7
Residue Composition
number
0
A
5
R
0
N
0
D
4
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
1
F
0
P
1
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
17
C96H148N34O21S4
2242.69
10.10
+6
-0.57
-0.829
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against E. coli demonstrated in vitro.
Evidence 2 Activity

Activity

2% Hemolysis
Toxicity
190 µM
Hemolytic Cytotoxic
2% Hemolysis | 190 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Improved strategy for recombinant production and purification of antimicrobial peptide tachyplesin I and its analogs with high cell selectivity. | Biotechnol Appl Biochem | 2017
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human embryonic fibroblasts

Target

Human embryonic fibroblasts

Source & Reference

NA
DBAASP
Improved strategy for recombinant production and purification of antimicrobial peptide tachyplesin I and its analogs with high cell selectivity. | Biotechnol Appl Biochem | 2017
Evidence 4 Activity

Activity

50% Cell death
Toxicity
85 µM
Cytotoxic
50% Cell death | 85 | µM | target cell: Human embryonic fibroblasts

Target

Human embryonic fibroblasts

Source & Reference

NA
DBAASP
Improved strategy for recombinant production and purification of antimicrobial peptide tachyplesin I and its analogs with high cell selectivity. | Biotechnol Appl Biochem | 2017
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.26549611] MHC2=190 µM against human red blood cells | Cytotoxicity: [Ref.26549611] The cell viability of human embryonic fibroblasts HEF is 90.6%, 92.9%, 84.1%, 70.6% and 34.1% at peptide concentrations of 6.25, 12.5, 25, 50 and 100 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biotechnol Appl Biochem. 2017 Jan 64(1):35-42. doi: 10.1002/bab.1456.