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Peptide record

TPDB13023

Macropin 2 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB13023
Macropin 2
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GTGLPMSERRKIMLMMR
Physicochemical Analysis
C83H151N27O22S4
ANDCQHFWYV
M
2007.52
12.12
4
1
7
+3
3.83
-0.300
68.82
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
1
E
0
Q
2
G
0
H
1
I
2
L
1
K
4
M
0
F
1
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 1 L: 2 K: 1 M: 4 F: 0 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
17
C83H151N27O22S4
2007.52
12.12
+3
3.83
-0.300
Free
L
Not Available
Free
Antibacterial
Venom, the solitary beeMacropis fulvipes
Evidence Records 5 records
Evidence 1 Activity

Activity

Not Available
Anticancer

Target

Not Available
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 3 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 4 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Rat epithelial cells IEC-6, CRL-1592

Target

Rat epithelial cells IEC-6, CRL-1592

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 5 Activity

Activity

IC50
Toxicity
200 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: IC50>200 µM | Cytotoxicity: HUVEC: IC50> 100 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2012 Jan 33(1):18-26.