Back to search

Peptide record

TPDB13002

Antibacterial Anticancer Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB13002
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GWWRRTVAKVRNAGRK
Physicochemical Analysis
C86H141N33O19
DCEQHILMFPSY
R
1941.28
12.88
6
0
6
+6
1.90
-1.287
48.75
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
566.64
2
Residue Composition
number
2
A
4
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
1
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 4 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 1 W: 2 Y: 0 V: 2
Chemical Descriptors
16
C86H141N33O19
1941.28
12.88
+6
1.90
-1.287
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.4 µM

Target

C. glutamicum ATCC 13032

Source & Reference

NA

Other

Active against C. glutamicum ATCC 13032 (MIC 0.4 uM), S.aureus ATCC 9144 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 25 uM), and E. coli ATCC
Evidence 2 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

S.aureus ATCC 9144

Source & Reference

NA

Other

Active against C. glutamicum ATCC 13032 (MIC 0.4 uM), S.aureus ATCC 9144 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 25 uM), and E. coli ATCC 25922 (MIC 6.3 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
25 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

NA

Other

Active against C. glutamicum ATCC 13032 (MIC 0.4 uM), S.aureus ATCC 9144 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 25 uM), and E. coli ATCC 25922 (MIC 6.3 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
6.3 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

(MIC 0.4 uM), S.aureus ATCC 9144 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 25 uM), and E. coli ATCC 25922 (MIC 6.3 uM).
Evidence 5 Activity

Activity

0% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
0% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity Relationship Studies of Shortened Analogues of the Antimicrobial Peptide EeCentrocin 1 From the Sea Urchin Echinus Esculentus. | J Pept Sci | 2019
Evidence 6 Activity

Activity

5% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
5% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity Relationship Studies of Shortened Analogues of the Antimicrobial Peptide EeCentrocin 1 From the Sea Urchin Echinus Esculentus. | J Pept Sci | 2019
Evidence 7 Activity

Activity

IC50
Toxicity
>200 µM
Cytotoxic
IC50 | >200 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Structure-activity Relationship Studies of Shortened Analogues of the Antimicrobial Peptide EeCentrocin 1 From the Sea Urchin Echinus Esculentus. | J Pept Sci | 2019
Evidence 8 Activity

Activity

IC50
Toxicity
200 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 0% Hemolysis=25 µM 5% Hemolysis=200 µM | Cytotoxicity: MRC-5: IC50>200 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2020 Feb 26(2):e3233