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Peptide record

TPDB12988

Antibacterial Antifungal Hemolysis Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB12988
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 16-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GLWDVIKKVASVIGGL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C78H131N19O20
RNCEQHMFPTY
GV
1655.01
9.88
2
1
9
+1
-0.97
1.050
158.12
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
3.32
1
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
0
Q
3
G
0
H
2
I
2
L
2
K
0
M
0
F
0
P
1
S
0
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 2 L: 2 K: 2 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 3
Chemical Descriptors
16 reviewed residue count
C78H131N19O20 sequence-only estimate (linear, free termini)
1655.01 sequence-only estimate (linear, free termini)
9.88 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
-0.97 sequence-only estimate (linear, free termini)
1.050 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
16.85 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 16.85 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Understanding interactions of Citropin 1.1 analogues with model membranes and their influence on biological activity. | Peptides | 2019
Evidence 2 Activity

Activity

IC50
Toxicity
>32 µg/mL
Cytotoxic
IC50 | >32 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Understanding interactions of Citropin 1.1 analogues with model membranes and their influence on biological activity. | Peptides | 2019
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis