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Peptide record

TPDB12987

Antibacterial Anticancer Antifungal Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB12987
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SFLTTVKKLVTNLAAL
Physicochemical Analysis
C80H139N19O22
RDCEQGHIMPWY
L
1719.10
10.60
2
0
9
+2
-0.62
0.988
146.25
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
5
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
2
K
0
M
1
F
0
P
1
S
3
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 2 M: 0 F: 1 P: 0 S: 1 T: 3 W: 0 Y: 0 V: 2
Chemical Descriptors
16
C80H139N19O22
1719.10
10.60
+2
-0.62
0.988
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
178 µM
Hemolytic Cytotoxic
50% Hemolysis | 178 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Bioevaluation of Ranatuerin-2Pb from the Frog Skin Secretion of Rana pipiens and its Truncated Analogues. | Biomolecules | 2019
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
7 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31242693] 7% hemolysis at 16 µM, 18% hemolysis at 32 µM, 20% hemolysis at 64 µM, 40% hemolysis at 128 µM, 70% hemolysis at 256 µM, 100% hemolysis at 512 µM on horse erythrocytes. | Cytotoxicity: [Ref.31242693] RPb only possessed inhibitory effect on the proliferation of H157 with the IC value of 6.856 µM, while showed no inhibitory effect on the proliferation of MCF-7, U251MG, PC-3 and MDA-MB-435s. DETAILED DATA: ①The cell viabillity of NCI-H157 induced by RPb is 98.7%, 102.5%, 96.9%, 98.1%, 38.1%, 9.4% at peptide concentrations of 0.001, 0.01, 0.1, 1, 10, 100 µM, while the cell viability induced by Melittin is 100%, 95%, 89.4%, 41.2%, 16.2% and 16.2% at 0.001, 0.01, 0.1, 1, 10, 100 µM. ②The cell viability of MCF-7 induced by RPb is 100.6%, 92.5%, 90%, 99.4%, 36.2% and 11.2% at peptide concentrations of 0.001, 0.01, 0.1, 1, 10, 100 µM, , while the cell viability induced by Melittin is 100%, 98.1%, 92.5%, 7.5%, 8.7% and 8.7% at 0.001, 0.01, 0.1, 1, 10, 100 µM. ③The cell viability of U251-MG induced by RPb is 105%, 103.1%, 109.4%, 102.5%, 105.6% and 13.1% at peptide concentrations of 0.001, 0.01, 0.1, 1, 10, 100 µM, while the cell viability induced by Melittin is 99.4%, 99.4%, 75.6%, 18.7%, 11.9% and 18.1% at 0.001, 0.01, 0.1, 1, 10, 100 µM.④The cell viability of PC-3 induced by RPa is 108.8%, 103.8%, 118.1%, 125.6%, 116.9% and 68.8% at peptide concentrations of 0.001, 0.01, 0.1, 1, 10, 100 µM, while the cell viability induced by Melittin is 110%, 113.1%, 109.4%, 33.1%, 16.9% and 16.2% at 0.001, 0.01, 0.1, 1, 10, 100 µM. ⑤The cell viability of MDA-MB-435S induced by RPa is 98.1%, 95%, 100.6%, 97.5%, 80.6% and 43.1%, while the cell viability induced by Melittin is 100%, 93.1%, 82.5%, 18.8%, 18.8% and 18.1%.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biomolecules. 2019 Jun 25 9(6):249. doi: 10.3390/biom9060249.