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Peptide record

TPDB12981

Antibacterial Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB12981
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 16-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GGHGRRWKIVVIRWRR
Physicochemical Analysis
C92H150N36O17
ANDCEQLMFPSTY
R
2032.43
13.00
7
0
6
+6
1.85
-0.950
85.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
541.22
0
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
3
G
1
H
2
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 1 I: 2 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 2
Chemical Descriptors
16
C92H150N36O17
2032.43
13.00
+6
1.85
-0.950
Evidence Records 2 records
Evidence 1 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Cu-ATCUN Derivatives of Sub5 Exhibit Enhanced Antimicrobial Activity via Multiple Modes of Action. | ACS Chem Biol | 2019
Evidence 2 Activity

Activity

IC50
Toxicity
132.5±34.0 µM
Cytotoxic
IC50 | 132.5±34.0 | µM | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Enhanced Synergism and Mechanism of Action Studies of Synthetic Antimicrobial Metallopeptides | ChemMedChem | 2021