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Peptide record

TPDB12979

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB12979
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse CAFPdb dbAMP dbAMP 3.0 Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
FLPALAGIAGLLGKIF
Physicochemical Analysis
C80H129N17O17
RNDCEQHMSTWYV
L
1601.01
10.10
1
0
11
+1
-4.16
1.781
165.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
2
I
4
L
1
K
0
M
2
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 2 L: 4 K: 1 M: 0 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C80H129N17O17
1601.01
10.10
+1
-4.16
1.781
Evidence Records 41 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

Staphylococcus aureus ST1065

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ S. aureus ATCC 25923, S. aureus ATCC 43300, S. aureus ATCC BAA-44, S. aureus ST1065 (MIC 3.1 uM), L. ivanovii (MIC 5 uM), E. faecalis ATCC 29212 (MIC 12.5 uM), B. megaterium (MIC 1.6 uM)
Evidence 2 Activity

Activity

MIC
Antibacterial
5 µM

Target

L. ivanovii

Source & Reference

dbAMP

Other

s ATCC 25923, S. aureus ATCC 43300, S. aureus ATCC BAA-44, S. aureus ST1065 (MIC 3.1 uM), L. ivanovii (MIC 5 uM), E. faecalis ATCC 29212 (MIC 12.5 uM), B. megaterium (MIC 1.6 uM), Gram- E. coli ATCC 259
Evidence 3 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP

Other

ATCC 43300, S. aureus ATCC BAA-44, S. aureus ST1065 (MIC 3.1 uM), L. ivanovii (MIC 5 uM), E. faecalis ATCC 29212 (MIC 12.5 uM), B. megaterium (MIC 1.6 uM), Gram- E. coli ATCC 25922, E. coli ATCC 35218, E. coli ML-35p
Evidence 4 Activity

Activity

MIC
Antibacterial
1.6 µM

Target

B. megaterium

Source & Reference

dbAMP

Other

aureus ST1065 (MIC 3.1 uM), L. ivanovii (MIC 5 uM), E. faecalis ATCC 29212 (MIC 12.5 uM), B. megaterium (MIC 1.6 uM), Gram- E. coli ATCC 25922, E. coli ATCC 35218, E. coli ML-35p (MIC 25-50 uM), P. aerugino
Evidence 5 Activity

Activity

MIC
Antibacterial
25-50 µM

Target

Escherichia coli ML-35p

Source & Reference

dbAMP

Other

(MIC 12.5 uM), B. megaterium (MIC 1.6 uM), Gram- E. coli ATCC 25922, E. coli ATCC 35218, E. coli ML-35p (MIC 25-50 uM), P. aeruginosa ATCC 27853 (MIC 60 uM), A. baumannii ATCC 19606 (MIC 25 uM), K. pneumoniae
Evidence 6 Activity

Activity

MIC
Antibacterial
60 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

MIC 1.6 uM), Gram- E. coli ATCC 25922, E. coli ATCC 35218, E. coli ML-35p (MIC 25-50 uM), P. aeruginosa ATCC 27853 (MIC 60 uM), A. baumannii ATCC 19606 (MIC 25 uM), K. pneumoniae ATCC 13883, S. enterica (MIC 100 uM),
Evidence 7 Activity

Activity

MIC
Antibacterial
25 µM

Target

A. baumannii ATCC 19606

Source & Reference

dbAMP

Other

E. coli ATCC 35218, E. coli ML-35p (MIC 25-50 uM), P. aeruginosa ATCC 27853 (MIC 60 uM), A. baumannii ATCC 19606 (MIC 25 uM), K. pneumoniae ATCC 13883, S. enterica (MIC 100 uM), yeast C. parapsilosis ATCC 22019 (MI
Evidence 8 Activity

Activity

MIC
Antibacterial
100 µM

Target

S. enterica

Source & Reference

dbAMP

Other

sa ATCC 27853 (MIC 60 uM), A. baumannii ATCC 19606 (MIC 25 uM), K. pneumoniae ATCC 13883, S. enterica (MIC 100 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), and C.albican
Evidence 9 Activity

Activity

MIC
Antibacterial
50 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP

Other

umannii ATCC 19606 (MIC 25 uM), K. pneumoniae ATCC 13883, S. enterica (MIC 100 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), and C.albicans ATCC 90028 (MIC >100 uM). Temporin-SHe demon
Evidence 10 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

S. cerevisiae

Source & Reference

dbAMP

Other

oniae ATCC 13883, S. enterica (MIC 100 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), and C.albicans ATCC 90028 (MIC >100 uM). Temporin-SHe demonstrated dose-dependent anti-L
Evidence 11 Activity

Activity

MIC
Antibacterial
>100 µM

Target

C.albicans ATCC 90028

Source & Reference

dbAMP

Other

C 100 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), and C.albicans ATCC 90028 (MIC >100 uM). Temporin-SHe demonstrated dose-dependent anti-Leishmania effects against promastigote fo
Evidence 12 Activity

Activity

IC50
Antibacterial
4.6-11.5 µM

Target

L. major

Source & Reference

dbAMP

Other

ia effects against promastigote forms (insect stage) of L. infantum, L. braziliensis, and L. major (IC50 4.6-11.5 uM).
Evidence 13 Activity

Activity

MIC
Antifungal
3.1 µM

Target

Staphylococcus aureus ST1065

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+ S. aureus ATCC 25923, S. aureus ATCC 43300, S. aureus ATCC BAA-44, S. aureus ST1065 (MIC 3.1 uM), L. ivanovii (MIC 5 uM), E. faecalis ATCC 29212 (MIC 12.5 uM), B. megaterium (MIC 1.6 uM)
Evidence 14 Activity

Activity

MIC
Antifungal
5 µM

Target

L. ivanovii

Source & Reference

dbAMP CAFPdb

Other

s ATCC 25923, S. aureus ATCC 43300, S. aureus ATCC BAA-44, S. aureus ST1065 (MIC 3.1 uM), L. ivanovii (MIC 5 uM), E. faecalis ATCC 29212 (MIC 12.5 uM), B. megaterium (MIC 1.6 uM), Gram- E. coli ATCC 259
Evidence 15 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP CAFPdb

Other

ATCC 43300, S. aureus ATCC BAA-44, S. aureus ST1065 (MIC 3.1 uM), L. ivanovii (MIC 5 uM), E. faecalis ATCC 29212 (MIC 12.5 uM), B. megaterium (MIC 1.6 uM), Gram- E. coli ATCC 25922, E. coli ATCC 35218, E. coli ML-35p
Evidence 16 Activity

Activity

MIC
Antifungal
1.6 µM

Target

B. megaterium

Source & Reference

dbAMP CAFPdb

Other

aureus ST1065 (MIC 3.1 uM), L. ivanovii (MIC 5 uM), E. faecalis ATCC 29212 (MIC 12.5 uM), B. megaterium (MIC 1.6 uM), Gram- E. coli ATCC 25922, E. coli ATCC 35218, E. coli ML-35p (MIC 25-50 uM), P. aerugino
Evidence 17 Activity

Activity

MIC
Antifungal
25-50 µM

Target

Escherichia coli ML-35p

Source & Reference

dbAMP CAFPdb

Other

(MIC 12.5 uM), B. megaterium (MIC 1.6 uM), Gram- E. coli ATCC 25922, E. coli ATCC 35218, E. coli ML-35p (MIC 25-50 uM), P. aeruginosa ATCC 27853 (MIC 60 uM), A. baumannii ATCC 19606 (MIC 25 uM), K. pneumoniae
Evidence 18 Activity

Activity

MIC
Antifungal
60 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb

Other

MIC 1.6 uM), Gram- E. coli ATCC 25922, E. coli ATCC 35218, E. coli ML-35p (MIC 25-50 uM), P. aeruginosa ATCC 27853 (MIC 60 uM), A. baumannii ATCC 19606 (MIC 25 uM), K. pneumoniae ATCC 13883, S. enterica (MIC 100 uM),
Evidence 19 Activity

Activity

MIC
Antifungal
25 µM

Target

A. baumannii ATCC 19606

Source & Reference

dbAMP CAFPdb

Other

E. coli ATCC 35218, E. coli ML-35p (MIC 25-50 uM), P. aeruginosa ATCC 27853 (MIC 60 uM), A. baumannii ATCC 19606 (MIC 25 uM), K. pneumoniae ATCC 13883, S. enterica (MIC 100 uM), yeast C. parapsilosis ATCC 22019 (MI
Evidence 20 Activity

Activity

MIC
Antifungal
100 µM

Target

S. enterica

Source & Reference

dbAMP CAFPdb

Other

sa ATCC 27853 (MIC 60 uM), A. baumannii ATCC 19606 (MIC 25 uM), K. pneumoniae ATCC 13883, S. enterica (MIC 100 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), and C.albican
Evidence 21 Activity

Activity

MIC
Antifungal
50 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP CAFPdb

Other

umannii ATCC 19606 (MIC 25 uM), K. pneumoniae ATCC 13883, S. enterica (MIC 100 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), and C.albicans ATCC 90028 (MIC >100 uM). Temporin-SHe demon
Evidence 22 Activity

Activity

MIC
Antifungal
12.5 µM

Target

S. cerevisiae

Source & Reference

dbAMP CAFPdb

Other

oniae ATCC 13883, S. enterica (MIC 100 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), and C.albicans ATCC 90028 (MIC >100 uM). Temporin-SHe demonstrated dose-dependent anti-L
Evidence 23 Activity

Activity

MIC
Antifungal
>100 µM

Target

C.albicans ATCC 90028

Source & Reference

dbAMP CAFPdb

Other

C 100 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), and C.albicans ATCC 90028 (MIC >100 uM). Temporin-SHe demonstrated dose-dependent anti-Leishmania effects against promastigote fo
Evidence 24 Activity

Activity

IC50
Antifungal
4.6-11.5 µM

Target

L. major

Source & Reference

dbAMP CAFPdb

Other

ia effects against promastigote forms (insect stage) of L. infantum, L. braziliensis, and L. major (IC50 4.6-11.5 uM).
Evidence 25 Activity

Activity

MIC
Antiparasitic
3.1 µM

Target

Staphylococcus aureus ST1065

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram+ S. aureus ATCC 25923, S. aureus ATCC 43300, S. aureus ATCC BAA-44, S. aureus ST1065 (MIC 3.1 uM), L. ivanovii (MIC 5 uM), E. faecalis ATCC 29212 (MIC 12.5 uM), B. megaterium (MIC 1.6 uM)
Evidence 26 Activity

Activity

MIC
Antiparasitic
5 µM

Target

L. ivanovii

Source & Reference

dbAMP 3.0

Other

s ATCC 25923, S. aureus ATCC 43300, S. aureus ATCC BAA-44, S. aureus ST1065 (MIC 3.1 uM), L. ivanovii (MIC 5 uM), E. faecalis ATCC 29212 (MIC 12.5 uM), B. megaterium (MIC 1.6 uM), Gram- E. coli ATCC 259
Evidence 27 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP 3.0

Other

ATCC 43300, S. aureus ATCC BAA-44, S. aureus ST1065 (MIC 3.1 uM), L. ivanovii (MIC 5 uM), E. faecalis ATCC 29212 (MIC 12.5 uM), B. megaterium (MIC 1.6 uM), Gram- E. coli ATCC 25922, E. coli ATCC 35218, E. coli ML-35p
Evidence 28 Activity

Activity

MIC
Antiparasitic
1.6 µM

Target

B. megaterium

Source & Reference

dbAMP 3.0

Other

aureus ST1065 (MIC 3.1 uM), L. ivanovii (MIC 5 uM), E. faecalis ATCC 29212 (MIC 12.5 uM), B. megaterium (MIC 1.6 uM), Gram- E. coli ATCC 25922, E. coli ATCC 35218, E. coli ML-35p (MIC 25-50 uM), P. aerugino
Evidence 29 Activity

Activity

MIC
Antiparasitic
25-50 µM

Target

Escherichia coli ML-35p

Source & Reference

dbAMP 3.0

Other

(MIC 12.5 uM), B. megaterium (MIC 1.6 uM), Gram- E. coli ATCC 25922, E. coli ATCC 35218, E. coli ML-35p (MIC 25-50 uM), P. aeruginosa ATCC 27853 (MIC 60 uM), A. baumannii ATCC 19606 (MIC 25 uM), K. pneumoniae
Evidence 30 Activity

Activity

MIC
Antiparasitic
60 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP 3.0

Other

MIC 1.6 uM), Gram- E. coli ATCC 25922, E. coli ATCC 35218, E. coli ML-35p (MIC 25-50 uM), P. aeruginosa ATCC 27853 (MIC 60 uM), A. baumannii ATCC 19606 (MIC 25 uM), K. pneumoniae ATCC 13883, S. enterica (MIC 100 uM),
Evidence 31 Activity

Activity

MIC
Antiparasitic
25 µM

Target

A. baumannii ATCC 19606

Source & Reference

dbAMP 3.0

Other

E. coli ATCC 35218, E. coli ML-35p (MIC 25-50 uM), P. aeruginosa ATCC 27853 (MIC 60 uM), A. baumannii ATCC 19606 (MIC 25 uM), K. pneumoniae ATCC 13883, S. enterica (MIC 100 uM), yeast C. parapsilosis ATCC 22019 (MI
Evidence 32 Activity

Activity

MIC
Antiparasitic
100 µM

Target

S. enterica

Source & Reference

dbAMP 3.0

Other

sa ATCC 27853 (MIC 60 uM), A. baumannii ATCC 19606 (MIC 25 uM), K. pneumoniae ATCC 13883, S. enterica (MIC 100 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), and C.albican
Evidence 33 Activity

Activity

MIC
Antiparasitic
50 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP 3.0

Other

umannii ATCC 19606 (MIC 25 uM), K. pneumoniae ATCC 13883, S. enterica (MIC 100 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), and C.albicans ATCC 90028 (MIC >100 uM). Temporin-SHe demon
Evidence 34 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

S. cerevisiae

Source & Reference

dbAMP 3.0

Other

oniae ATCC 13883, S. enterica (MIC 100 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), and C.albicans ATCC 90028 (MIC >100 uM). Temporin-SHe demonstrated dose-dependent anti-L
Evidence 35 Activity

Activity

MIC
Antiparasitic
>100 µM

Target

C.albicans ATCC 90028

Source & Reference

dbAMP 3.0

Other

C 100 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), and C.albicans ATCC 90028 (MIC >100 uM). Temporin-SHe demonstrated dose-dependent anti-Leishmania effects against promastigote fo
Evidence 36 Activity

Activity

IC50
Antiparasitic
4.6-11.5 µM

Target

L. major

Source & Reference

dbAMP 3.0

Other

ia effects against promastigote forms (insect stage) of L. infantum, L. braziliensis, and L. major (IC50 4.6-11.5 uM).
Evidence 37 Activity

Activity

% Hemolysis
Hemolysis
22 84 %
Human erythrocytes: 22% Hemolysis=12.5µM 84% Hemolysis=25µM

Target

Human erythrocytes

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Int J Mol Sci. 2020 Sep 13 21(18):6713.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 38 Activity

Activity

22% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
22% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Functional Characterization of Temporin-SHe, a New Broad-Spectrum Antibacterial and Leishmanicidal Temporin-SH Paralog from the Sahara Frog (Pelophylax saharicus). | Int J Mol Sci | 2020
Evidence 39 Activity

Activity

84% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
84% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Functional Characterization of Temporin-SHe, a New Broad-Spectrum Antibacterial and Leishmanicidal Temporin-SH Paralog from the Sahara Frog (Pelophylax saharicus). | Int J Mol Sci | 2020
Evidence 40 Activity

Activity

% Hemolysis
Toxicity
22 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 22% Hemolysis=12.5µM 84% Hemolysis=25µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2020 Sep 13 21(18):6713.
Evidence 41 Hemolysis

Activity

22 84 %
% Hemolysis
Human erythrocytes: 22% Hemolysis=12.5µM 84% Hemolysis=25µM
Hemolysis

Target

Human erythrocytes

Source & Reference

PD_Hemolysis
Int J Mol Sci. 2020 Sep 13 21(18):6713.
DRAMP4
PD_Hemolysis