TPDB

3D PDB MODEL

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TPDB ID TPDB12977

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 16-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.

Sequence

VMWCYVFGYGFNCAVW

FASTA

>TPDB12977|Antibacterial;Antifungal|length=16
VMWCYVFGYGFNCAVW

Formula C95H121N19O20S3

Absent Amino Acids RDEQHILKPST

Common Amino Acids V

Mass 1945.30

PI 5.18

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 11

Net Charge -0

Boman Index -8.07

Hydrophobicity 1.137

Aliphatic Index 60.62

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 14105

Absorbance 280nm 725.08

Polar Residues 5

number

1

A

0

R

1

N

0

D

2

C

0

E

0

Q

2

G

0

H

0

I

0

L

0

K

1

M

2

F

0

P

0

S

0

T

2

W

2

Y

3

V

Amino Acid Distribution

A: 1 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 1 F: 2 P: 0 S: 0 T: 0 W: 2 Y: 2 V: 3

Length

16

Formula

C95H121N19O20S3

Mass

1945.30

PI

5.18

Net Charge

-0

Boman Index

-8.07

Hydrophobicity

1.137

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 7.5 ug/mL

Target

Target Organism M. tuberculosis

Source & Reference

Database Source NA

Other

Evidence Text

Active against M. tuberculosis (MIC 7.5 ug/mL) (Anti-TB), M. smegmatis (MIC 2.5 ug/mL), acid-fast. At 4x MIC, it is able to kill 99.99%

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.5 ug/mL

Target

Target Organism M. smegmatis

Source & Reference

Database Source NA

Other

Evidence Text

Active against M. tuberculosis (MIC 7.5 ug/mL) (Anti-TB), M. smegmatis (MIC 2.5 ug/mL), acid-fast. At 4x MIC, it is able to kill 99.99% M. smegmatis in 8 h.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 7.5 ug/mL

Target

Target Organism M. tuberculosis

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against M. tuberculosis (MIC 7.5 ug/mL) (Anti-TB), M. smegmatis (MIC 2.5 ug/mL), acid-fast. At 4x MIC, it is able to kill 99.99%

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.5 ug/mL

Target

Target Organism M. smegmatis

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against M. tuberculosis (MIC 7.5 ug/mL) (Anti-TB), M. smegmatis (MIC 2.5 ug/mL), acid-fast. At 4x MIC, it is able to kill 99.99% M. smegmatis in 8 h.