Back to search

Peptide record

TPDB12968

PenLys Antibacterial Anticancer Antifungal Cell-penetrating Peptides Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB12968
PenLys
Antibacterial Anticancer Antifungal Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb CPPsite3.0 MLCPP 2.0
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KQIKIWFQNKKMKWKK
Physicochemical Analysis
C104H168N28O20S1
ARDCEGHLPSTYV
K
2162.71
11.29
7
0
6
+7
2.83
-1.619
48.75
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
11000
508.62
3
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
2
Q
0
G
0
H
2
I
0
L
7
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 7 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
16
C104H168N28O20S1
2162.71
11.29
+7
2.83
-1.619
Free
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 3 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2 Cells

Assay & Model

Male Sprague-Dawley rats (252±7 g)
Male Sprague-Dawley rats (252±7 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Insulin
PenLys analogue did not promote insulin transport at any of the three pH values tested
In vitro and in vivo
CCCCCCGGGCCCCCCC
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
50% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure. | Biochim Biophys Acta | 2013
Evidence 3 Activity

Activity

HC50
Toxicity
128 µM
Hemolytic
Hemolytic_activity: [Ref.23085001] HC50>128 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2013 Feb 1828(2):223-232. doi: 10.1016/j.bbamem.2012.10.010.
Additional Detail Fields 1 fields
CCCCCCGGGCCCCCCC