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Peptide record

TPDB12949

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB12949
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 15-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
NKVKEWIKYLKSKFK
Physicochemical Analysis
C94H151N23O21
ARDCQGHMPT
K
1939.37
10.60
6
1
6
+5
3.79
-1.207
71.33
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
6990
360.43
3
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
1
E
0
Q
0
G
0
H
1
I
1
L
6
K
0
M
1
F
0
P
1
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 6 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
15
C94H151N23O21
1939.37
10.60
+5
3.79
-1.207
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Design and Engineering of Antimicrobial Peptides Based on LPcin-YK3, an Antimicrobial Peptide Derivative from Bovine Milk. | J Microbiol Biotechnol | 2018
Evidence 2 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Human Lung Fibroblasts

Target

Human Lung Fibroblasts

Source & Reference

NA
DBAASP
Design and Engineering of Antimicrobial Peptides Based on LPcin-YK3, an Antimicrobial Peptide Derivative from Bovine Milk. | J Microbiol Biotechnol | 2018
Evidence 3 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Mouse fibroblasts L929

Target

Mouse fibroblasts L929

Source & Reference

NA
DBAASP
Design and Engineering of Antimicrobial Peptides Based on LPcin-YK3, an Antimicrobial Peptide Derivative from Bovine Milk. | J Microbiol Biotechnol | 2018
Evidence 4 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Design and Engineering of Antimicrobial Peptides Based on LPcin-YK3, an Antimicrobial Peptide Derivative from Bovine Milk. | J Microbiol Biotechnol | 2018
Evidence 5 Activity

Activity

IC50
Toxicity
71.9 µM
Cytotoxic
IC50 | 71.9 | µM | target cell: Chinese hamster ovary cells CHO-K1

Target

Chinese hamster ovary cells CHO-K1

Source & Reference

NA
DBAASP
Design and Engineering of Antimicrobial Peptides Based on LPcin-YK3, an Antimicrobial Peptide Derivative from Bovine Milk. | J Microbiol Biotechnol | 2018