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Peptide record

TPDB12948

Antibacterial Anticancer Hemolysis Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB12948
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis ToxinPred 3.0
standard
No
A 15-aa standard-residue multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, PD_Hemolysis, and other sources, with an available 3D structural model.
Sequence
IHKLVKLWLNLGKKF
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C91H149N23O17
ARDCEQMPSTY
LK
1837.33
11.00
5
0
8
+4
-0.09
0.207
149.33
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
2.99
1
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
1
H
1
I
4
L
4
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 4 K: 4 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
15 reviewed residue count
C91H149N23O17 sequence-only estimate (linear, free termini)
1837.33 sequence-only estimate (linear, free termini)
11.00 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
-0.09 sequence-only estimate (linear, free termini)
0.207 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
39.3 µM
Hemolytic Cytotoxic
10% Hemolysis | 39.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of antimicrobial and cytolytic peptides by computational analysis of bacterial, algal, and invertebrate proteomes. | Amino Acids | 2020
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 10% Hemolysis=39.3 µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2020 Oct 52(10):1403-1412
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis