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Peptide record

TPDB12944

Antibacterial Anticancer Antifungal Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB12944
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 15-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
AVKKLLRWWSRWWKK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C103H155N29O17
NDCEQGHIMFPTY
KW
2071.55
12.44
6
0
8
+6
2.03
-1.027
78.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
22000
10.62
1
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
4
K
0
M
0
F
0
P
1
S
0
T
4
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 4 M: 0 F: 0 P: 0 S: 1 T: 0 W: 4 Y: 0 V: 1
Chemical Descriptors
15 reviewed residue count
C103H155N29O17 sequence-only estimate (linear, free termini)
2071.55 sequence-only estimate (linear, free termini)
12.44 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
2.03 sequence-only estimate (linear, free termini)
-1.027 sequence-only estimate (linear, free termini)
Evidence Records 4 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
<200 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | <200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A small mycobacteriophage-derived peptide and its improved isomer restrict mycobacterial infection via dual mycobactericidal-immunoregulatory activities. | J Biol Chem | 2019
Evidence 2 Activity

Activity

0% Hemolysis
Toxicity
<200 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | <200 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
A small mycobacteriophage-derived peptide and its improved isomer restrict mycobacterial infection via dual mycobactericidal-immunoregulatory activities. | J Biol Chem | 2019
Evidence 3 Activity

Activity

0% Cytotoxicity
Toxicity
<200 µg/mL
Cytotoxic
0% Cytotoxicity | <200 | µg/mL | target cell: Murine peritoneal macrophages

Target

Murine peritoneal macrophages

Source & Reference

NA
DBAASP
A small mycobacteriophage-derived peptide and its improved isomer restrict mycobacterial infection via dual mycobactericidal-immunoregulatory activities. | J Biol Chem | 2019
Evidence 4 Activity

Activity

0% Cytotoxicity
Toxicity
<200 µg/mL
Cytotoxic
0% Cytotoxicity | <200 | µg/mL | target cell: Vero E6 cells

Target

Vero E6 cells

Source & Reference

NA
DBAASP
A small mycobacteriophage-derived peptide and its improved isomer restrict mycobacterial infection via dual mycobactericidal-immunoregulatory activities. | J Biol Chem | 2019