Back to search

Peptide record

TPDB12930

Antibacterial Antifungal Hemolysis Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB12930
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP PD_Hemolysis
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
VKRFKKFFRKFKKFV
Physicochemical Analysis
C103H161N27O16
ANDCEQGHILMPSTWY
K
2033.58
12.46
8
0
7
+8
2.05
-0.667
38.67
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
6
K
0
M
5
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 6 M: 0 F: 5 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
15
C103H161N27O16
2033.58
12.46
+8
2.05
-0.667
Evidence Records 10 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>320 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >320 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The antimicrobial peptide ZY4 combats multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii infection. | Proc Natl Acad Sci U S A | 2019
Evidence 2 Activity

Activity

31.7±4.2% Hemolysis
Toxicity
320 µg/mL
Hemolytic Cytotoxic
31.7±4.2% Hemolysis | 320 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The antimicrobial peptide ZY4 combats multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii infection. | Proc Natl Acad Sci U S A | 2019
Evidence 3 Activity

Activity

10% Hemolysis
Toxicity
>128 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | >128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo | J Med Chem | 2022
Evidence 4 Activity

Activity

LC50
Toxicity
128 µg/mL
Cytotoxic
LC50 | 128 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo | J Med Chem | 2022
Evidence 5 Activity

Activity

LC50
Toxicity
64 µg/mL
Cytotoxic
LC50 | 64 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo | J Med Chem | 2022
Evidence 6 Activity

Activity

LC50
Toxicity
100 µg/mL
Cytotoxic
LC50 | 100 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo | J Med Chem | 2022
Evidence 7 Activity

Activity

10% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 32 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo | J Med Chem | 2022
Evidence 8 Activity

Activity

LC90
Toxicity
128 µg/mL
Cytotoxic
LC90 | 128 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo | J Med Chem | 2022
Evidence 9 Activity

Activity

LC
Toxicity
128 µg/mL
Cytotoxic
LC | 128 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo | J Med Chem | 2022
Evidence 10 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis