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Peptide record

TPDB12923

Antibacterial Anticancer Hemolysis Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB12923
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
CVRRFPWWWPFLRRC
Physicochemical Analysis
C102H142N30O16S2
ANDEQGHIKMSTY
R
2108.56
11.93
4
0
7
+4
-4.64
-0.353
45.33
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
16625
788.45
2
Residue Composition
number
0
A
4
R
0
N
0
D
2
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
2
F
2
P
0
S
0
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 2 P: 2 S: 0 T: 0 W: 3 Y: 0 V: 1
Chemical Descriptors
15
C102H142N30O16S2
2108.56
11.93
+4
-4.64
-0.353
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
3.75 µM
Hemolytic Cytotoxic
50% Hemolysis | 3.75 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cyclic Tritrpticin Analogs with Distinct Biological Activities. | Probiotics Antimicrob Proteins | 2011
Evidence 2 Activity

Activity

IC50
Toxicity
26.2 µM
Cytotoxic
IC50 | 26.2 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. | Biochim Biophys Acta | 2020
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta Biomembr. 2020 Aug 1 1862(8):183228.
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis