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Peptide record

TPDB12916

Antibacterial Anticancer Antifungal Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB12916
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 15-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
YLARAIRRTLARLLL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C82H147N27O18
NDCEQGHKMFPSWV
L
1799.24
12.40
4
0
10
+4
1.83
0.593
176.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
0.83
2
Residue Composition
number
3
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
5
L
0
K
0
M
0
F
0
P
0
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 3 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 5 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
15 reviewed residue count
C82H147N27O18 sequence-only estimate (linear, free termini)
1799.24 sequence-only estimate (linear, free termini)
12.40 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
1.83 sequence-only estimate (linear, free termini)
0.593 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Cell death
Toxicity
>128 µg/mL
Cytotoxic
50% Cell death | >128 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Computational antimicrobial peptide design and evaluation against multidrug-resistant clinical isolates of bacteria. | J Biol Chem | 2018
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2018 Mar 9 293(10):3492-3509.