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Peptide record

TPDB12908

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB12908
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 15-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KAAKAAKKAAKAAWK
Physicochemical Analysis
C71H124N22O16
RNDCEQGHILMFPSTYV
A
1541.90
11.21
6
0
9
+6
2.73
-0.660
53.33
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
356.70
0
Residue Composition
number
8
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
6
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 8 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
15
C71H124N22O16
1541.90
11.21
+6
2.73
-0.660
Evidence Records 3 records
Evidence 1 Activity

Activity

<1% Hemolysis
Toxicity
12.5-25 µM
Hemolytic Cytotoxic
<1% Hemolysis | 12.5-25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of doubly-stapled alanine/lysine-based peptides. | Bioorg Med Chem Lett | 2015
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
1 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.26235946] <1% hemolysis at 12.5 µM , <1% hemolysis at 25 µM against human red blood cells | Cytotoxicity: [Ref.26235946] No cytotoxic information found.

Target

erythrocytes

Source & Reference

NA
DRAMP
Bioorg Med Chem Lett. 2015 Sep 15 25(18):4016-9. doi: 10.1016/j.bmcl.2015.06.053.
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
1 %
Hemolytic
Hemolytic_activity: [Ref.26235946] <1% hemolysis against human red blood cells at 12.5 µM and <1% hemolysis at 25 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Bioorg Med Chem Lett. 2015 Sep 15 25(18):4016-9. doi: 10.1016/j.bmcl.2015.06.053. Epub 2015 Jun 19.