Back to search

Peptide record

TPDB12906

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB12906
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 15-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RFRPPIRRPPIRPPF
Physicochemical Analysis
C90H144N30O16
ANDCEQGHLKMSTWYV
P
1902.33
13.00
5
0
4
+5
3.87
-1.167
52.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
0
L
0
K
0
M
2
F
6
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 0 K: 0 M: 0 F: 2 P: 6 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C90H144N30O16
1902.33
13.00
+5
3.87
-1.167
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
64 µM

Target

Escherichia coli BW25113 or ATCC 25922

Source & Reference

NA

Other

active against Gram- E. coli BW25113 or ATCC 25922 (MIC 64 uM), A-baumannii ATCC 19606 (MIC >64 uM), S-enterica ATCC 14028 (MIC >64 uM), K-pneumoniae AT
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Search for Shorter Portions of the Proline-Rich Antimicrobial Peptide Fragment Bac5(1-25) That Retain Antimicrobial Activity by Blocking Protein Synthesis. | ChemMedChem | 2019
Evidence 3 Activity

Activity

0% Killing
Toxicity
<32 µM
Cytotoxic
0% Killing | <32 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Fragments of the Nonlytic Proline-Rich Antimicrobial Peptide Bac5 Kill Escherichia coli Cells by Inhibiting Protein Synthesis. | Antimicrob Agents Chemother | 2018