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Peptide record

TPDB12899

Antibacterial Anticancer Antifungal Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB12899
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia dbACP AFP-GFuse CAFPdb DRAMP
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, dbACP, and other sources, with an available 3D structural model.
Sequence
INWLKIAKKVKGML
Physicochemical Analysis
C78H136N20O16S1
RDCEQHFPSTY
K
1642.12
11.00
4
0
8
+4
0.47
0.293
139.29
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
334.93
1
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
2
L
4
K
1
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 2 K: 4 M: 1 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
14
C78H136N20O16S1
1642.12
11.00
+4
0.47
0.293
Evidence Records 7 records
Evidence 1 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Rat peritoneal mast cells

Target

Rat peritoneal mast cells

Source & Reference

NA
DBAASP
Structure-activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity. | Peptides | 2015
Evidence 2 Activity

Activity

20% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
20% Hemolysis | 100 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity. | Peptides | 2015
Evidence 3 Activity

Activity

35% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
35% Hemolysis | 200 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity. | Peptides | 2015
Evidence 4 Activity

Activity

IC50
Toxicity
>500 µg/mL
Cytotoxic
IC50 | >500 | µg/mL | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Antifungal Activity, Toxicity, and Membranolytic Action of a Mastoparan Analog Peptide | Front Cell Infect Microbiol | 2019
Evidence 5 Activity

Activity

35% Cell death
Toxicity
250 µg/mL
Cytotoxic
35% Cell death | 250 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Study of mastoparan analog peptides against Candida albicans and safety in zebrafish embryos (Danio rerio). | Future Microbiol | 2019
Evidence 6 Activity

Activity

LC50
Toxicity
13.02 µg/mL
Cytotoxic
LC50 | 13.02 | µg/mL | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
Study of mastoparan analog peptides against Candida albicans and safety in zebrafish embryos (Danio rerio). | Future Microbiol | 2019
Evidence 7 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.31867293]MK58911 was not toxic in lung fibroblasts (MRC5) and glioblastoma cells (U87) at tested concentrations, and a high IC50 of >500 µg/mL was observed in both mammalian cells.

Source & Reference

NA
DRAMP
Front Cell Infect Microbiol. 2019 Dec 6 9:419. doi: 10.3389/fcimb.2019.00419. eCollection 2019.