Back to search

Peptide record

TPDB12895

Antibacterial Antifungal Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB12895
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
GLFDIVKKVVGALG
Physicochemical Analysis
C67H114N16O17
RNCEQHMPSTWY
GV
1415.74
9.88
2
1
8
+1
0.72
1.200
152.86
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
0
Q
3
G
0
H
1
I
2
L
2
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 2 K: 2 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
14
C67H114N16O17
1415.74
9.88
+1
0.72
1.200
Evidence Records 2 records
Evidence 1 Activity

Activity

<=5% Hemolysis
Toxicity
16 µM
Hemolytic Cytotoxic
<=5% Hemolysis | 16 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Morphing of Amphipathic Helices to Explore the Activity and Selectivity of Membranolytic Antimicrobial Peptides. | Biochemistry | 2020
Evidence 2 Activity

Activity

50% Cell death
Toxicity
64 µM
Cytotoxic
50% Cell death | 64 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
Morphing of Amphipathic Helices to Explore the Activity and Selectivity of Membranolytic Antimicrobial Peptides. | Biochemistry | 2020