Back to search

Peptide record

TPDB12894

Antibacterial Antifungal Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB12894
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept PD_Hemolysis
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GLLDLLKLLLKAAG
Physicochemical Analysis
C68H124N16O17
RNCEQHIMFPSTWYV
L
1437.83
9.88
2
1
9
+1
-1.03
1.293
209.29
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
2
A
0
R
0
N
1
D
0
C
0
E
0
Q
2
G
0
H
0
I
7
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 7 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C68H124N16O17
1437.83
9.88
+1
-1.03
1.293
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
35 µM

Target

Escherichia coli

Source & Reference

NA

Other

Active against E. coli (MIc 35 uM) and S. aureus (10 uM).
Evidence 2 Activity

Activity

MIC
Antifungal
35 µM

Target

Escherichia coli

Source & Reference

Antifungipept

Other

Active against E. coli (MIc 35 uM) and S. aureus (10 uM).
Evidence 3 Activity

Activity

<5% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
<5% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Simulation-Guided Rational de Novo Design of a Small Pore-Forming Antimicrobial Peptide. | J Am Chem Soc | 2019
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
63±8 µM
Hemolytic Cytotoxic
50% Hemolysis | 63±8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Simulation-Guided Rational de Novo Design of a Small Pore-Forming Antimicrobial Peptide. | J Am Chem Soc | 2019
Evidence 5 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis