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Peptide record

TPDB12866

Antibacterial Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB12866
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 14-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
INWLAIAKKVAGML
Physicochemical Analysis
C72H122N18O16S1
RDCEQHFPSTY
A
1527.93
10.60
2
0
10
+2
-1.85
1.107
153.57
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
359.96
1
Residue Composition
number
3
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
2
L
2
K
1
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 2 K: 2 M: 1 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
14
C72H122N18O16S1
1527.93
10.60
+2
-1.85
1.107
Evidence Records 4 records
Evidence 1 Activity

Activity

20% Degranulation
Toxicity
40 µM
Cytotoxic
20% Degranulation | 40 | µM | target cell: Rat peritoneal mast cells

Target

Rat peritoneal mast cells

Source & Reference

NA
DBAASP
Structure-activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity. | Peptides | 2015
Evidence 2 Activity

Activity

50% Degranulation
Toxicity
210 µM
Cytotoxic
50% Degranulation | 210 | µM | target cell: Rat mast cells

Target

Rat mast cells

Source & Reference

NA
DBAASP
Structure-activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity. | Peptides | 2015
Evidence 3 Activity

Activity

80% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
80% Hemolysis | 100 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity. | Peptides | 2015
Evidence 4 Activity

Activity

100% Hemolysis
Toxicity
160 µM
Hemolytic Cytotoxic
100% Hemolysis | 160 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity. | Peptides | 2015